Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Medicinal Chemistry called Design and Synthesis of the Potent, Orally Available, Brain-Penetrable Arylpyrazole Class of Neuropeptide Y5 Receptor Antagonists, Author is Sato, Nagaaki; Takahashi, Toshiyuki; Shibata, Takunobu; Haga, Yuji; Sakuraba, Aya; Hirose, Masaaki; Sato, Miki; Nonoshita, Katsumasa; Koike, Yuko; Kitazawa, Hidefumi; Fujino, Naoko; Ishii, Yasuyuki; Ishihara, Akane; Kanatani, Akio; Fukami, Takehiro, which mentions a compound: 91912-53-7, SMILESS is NC1=CC(C2=CC=NC=C2)=NN1, Molecular C8H8N4, COA of Formula: C8H8N4.
Novel arylpyrazole derivatives were synthesized and evaluated as neuropeptide Y5 receptor antagonists. The 2,3-dihydro-1H-cyclopenta[a]naphthalene derivative I showed good binding affinity and antagonistic activity for the Y5 receptor. After intracerebroventricular administration in SD rats, (-)-I significantly inhibited food intake that was induced by the centrally administered Y5-preferring agonist, bovine pancreatic polypeptide, but had only a negligible effect on NPY-induced feeding.
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