The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Ethyl oxazole-5-carboxylate( cas:118994-89-1 ) is researched.Quality Control of Ethyl oxazole-5-carboxylate.Vedejs, Edwin; Luchetta, Leza M. published the article 《A Method for Iodination of Oxazoles at C-4 via 2-Lithiooxazoles》 about this compound( cas:118994-89-1 ) in Journal of Organic Chemistry. Keywords: iodination lithiation oxazole; coupling iodination lithiation oxazole. Let’s learn more about this compound (cas:118994-89-1).
Lithiation and sequential iodination of oxazole derivatives gave mixtures of 4-iodooxazole derivatives, 2-iodooxazole derivatives and 2,4-diiodooxazole derivatives Metalation of 5-(4-methylphenyl)oxazole and coupling with 4-iodo-5-(2-phenylethyl)oxazole gave the resp. 2,4′-bisoxazole.
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