New downstream synthetic route of 114080-95-4

In addition to the literature in the link below, there is a lot of literature about this compound(3-Chloropicolinamide)Formula: C6H5ClN2O, illustrating the importance and wide applicability of this compound(114080-95-4).

Formula: C6H5ClN2O. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 3-Chloropicolinamide, is researched, Molecular C6H5ClN2O, CAS is 114080-95-4, about The addition of hydroxylamine to derivatives of halopyridine carboxylic acids. Author is Dunn, A. D..

Cyanopyridines I (R = Cl, R1 = cyano, R2 = H; R = cyano, R1 = Cl, R2 = H; R = H, R1 = cyano, R2 = Cl) reacted with a MeOH solution of NH2OH and MeONa to give isoxazolopyridines. Thus, I (R = Cl, R1 = cyano, R2 = H) gave isoxazolopyridine II. However, I (R = H, R1 = Cl, R2 = cyano) reacted with the same reagent to give I (R, R1, same, R2 = CONH2), and I (R = H, R1 = Br, R2 = cyano) gave I [R, R1, same, R2 = C(:NOH)NH2]. No bicyclic products were formed . Esters I (R = Cl, R1 = CO2Me, R2 = H) reacted with the same reagent to give the hydroxamic acids I (R, R2, same, R1 = CONHOH). Similarly esters I (R = CO2Me, R1 = Br, R2 = H; R= H, R1 = Br, R2 = CO2Me) also gave the corresponding hydroxamic acids.

In addition to the literature in the link below, there is a lot of literature about this compound(3-Chloropicolinamide)Formula: C6H5ClN2O, illustrating the importance and wide applicability of this compound(114080-95-4).

Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem