So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Xing, Qi; Lv, Hui; Xia, Chungu; Li, Fuwei researched the compound: Ethyl oxazole-5-carboxylate( cas:118994-89-1 ).Reference of Ethyl oxazole-5-carboxylate.They published the article 《Palladium-catalyzed intermolecular carbonylative cross-coupling of heteroaryl C(sp2)-H bonds with amines: an efficient strategy for oxidative aminocarbonylation of azoles》 about this compound( cas:118994-89-1 ) in Chemical Communications (Cambridge, United Kingdom). Keywords: heteroarylamide preparation green chem; azole amine intermol oxidative aminocarbonylation palladium catalyst. We’ll tell you more about this compound (cas:118994-89-1).
An efficient palladium-catalyzed oxidative aminocarbonylation of azoles such as benzothiazole, 5-chloro benzoxazole, 4,5-dimethyl-1,3-thiazole, etc. has been developed. This system allows for intermol. carbonylative cross-coupling of aromatic C(sp2)-H bonds with simple amines RR1NH [R = H, CH2CH3, c-C6H11, etc.; R1 = C(H3)3, (CH2)2CH3, CH2C6H5, etc.; RR1 = -(CH2)2O(CH2)2-, -(CH2)5-], which has often been asked for, but has not been realized so far. It provides a straightforward approach to a variety of azol-2-amides RR1NC(O)R2 (R2 = 1,3-benzothiazol-2-yl, 5-chloro-1,3-benzoxazol-2-yl, dimethyl-1,3-thiazol-2-yl, etc.).
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