In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Formation of 2-iminothiazolidine-4-carboxylic acid in the cyanobromination of lanthionine, published in 1963, which mentions a compound: 2150-55-2, mainly applied to , HPLC of Formula: 2150-55-2.
A 5 ml. solution of lanthionine in 0.1N HCl was added to 5 ml. 5% aqueous NaCN and the mixture treated with 1 ml. NCBr solution (prepared by adding 5% aqueous NaCN to a saturated solution of Br till the solution was just colorless). After 3 consecutive boilings for 30 secs. and cooling for 3 min., the thiol content estimation was interfered with by incomplete removal of NCBr. The reaction mixture was, therefore, boiled for 10 min., but the quantity of thiol formed was not consistent and reproducibility of the results was very poor. Paper chromatography of the products in sec-BuOH-HCOOH-H2O (75:15:10) system showed the presence of 2-iminothiazolidine-4-carboxylic acid (I). In these experiments, HCl was converted to HCN, which was expelled on boiling and probably the high pH led to the formation of the acid.
This literature about this compound(2150-55-2)HPLC of Formula: 2150-55-2has given us a lot of inspiration, and I hope that the research on this compound(2-Amino-4,5-dihydrothiazole-4-carboxylic acid) can be further advanced. Maybe we can get more compounds in a similar way.