So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zanaletti, Riccardo; Bettinetti, Laura; Castaldo, Cristiana; Cocconcelli, Giuseppe; Comery, Thomas; Dunlop, John; Gaviraghi, Giovanni; Ghiron, Chiara; Haydar, Simon N.; Jow, Flora; Maccari, Laura; Micco, Iolanda; Nencini, Arianna; Scali, Carla; Turlizzi, Elisa; Valacchi, Michela researched the compound: 3-(Pyridin-4-yl)-1H-pyrazol-5-amine( cas:91912-53-7 ).Application In Synthesis of 3-(Pyridin-4-yl)-1H-pyrazol-5-amine.They published the article 《Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-Acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-Methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN15924, WAY-361789)》 about this compound( cas:91912-53-7 ) in Journal of Medicinal Chemistry. Keywords: acetyldiazepanyl pentanoic acid methoxyphenyl pyrazolyl amide synthesis cholinergic agonist; nicotinic acetylcholine receptor agonist discovery structure activity mol docking. We’ll tell you more about this compound (cas:91912-53-7).
Alpha-7 nicotinic acetylcholine receptors (α7 nAChR) are implicated in the modulation of many cognitive functions such as attention, working memory, and episodic memory. For this reason, α7 nAChR agonists represent promising therapeutic candidates for the treatment of cognitive impairment associated with Alzheimer’s disease (AD) and schizophrenia. A medicinal chem. effort, around our previously reported chem. series, permitted the discovery of a novel class of α7 nAChR agonists with improved selectivity, in particular against the α3 receptor subtype and better ADME profile. The exploration of this series led to the identification of 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide [(I), SEN15924, WAY-361789], a novel, full agonist of the α7 nAChR that was evaluated in vitro and in vivo. Compound I proved to be potent and selective, and it demonstrated a fair pharmacokinetic profile accompanied by efficacy in rodent behavioral cognition models (novel object recognition and auditory sensory gating).
There is still a lot of research devoted to this compound(SMILES：NC1=CC(C2=CC=NC=C2)=NN1)Application In Synthesis of 3-(Pyridin-4-yl)-1H-pyrazol-5-amine, and with the development of science, more effects of this compound(91912-53-7) can be discovered.