Application of 118994-89-1. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Ethyl oxazole-5-carboxylate, is researched, Molecular C6H7NO3, CAS is 118994-89-1, about The Application of C-H Functionalization in the Development of a Concise and Convergent Route to the Phosphatidylinositol-3-kinase Delta Inhibitor Nemiralisib.. Author is Bream, Robert N.; Clark, Hugh; Edney, Dean; Harsanyi, Antal; Hayler, John; Ironmonger, Alan; Mc Cleary, Nadine; Phillips, Natalie; Priestley, Catherine; Roberts, Alastair; Rushworth, Philip; Szeto, Peter; Webb, Michael R.; Wheelhouse, Katherine.
The development of an improved and scalable method for the manufacture of Nemiralisib, a phosphatidylinositol-3-kinase delta inhibitor was studied. Incorporation of three consecutive catalytic reactions, including a palladium-catalyzed C-H functionalization and an iridium-catalyzed borylation, significantly simplified and shortened the synthetic sequence. The revised route was successfully implemented in pilot plant on multikilogram scale to deliver >100 kg of product.
If you want to learn more about this compound(Ethyl oxazole-5-carboxylate)Application of 118994-89-1, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(118994-89-1).