So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Palmer, Brian D.; Denny, William A. researched the compound: 4-Bromo-1-methyl-2-nitro-1H-imidazole( cas:121816-79-3 ).Reference of 4-Bromo-1-methyl-2-nitro-1H-imidazole.They published the article 《Synthesis and reactions of brominated 2-nitroimidazoles》 about this compound( cas:121816-79-3 ) in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999). Keywords: bromoimidazole; imidazole bromination. We’ll tell you more about this compound (cas:121816-79-3).
Imidazoles reacted with N-bromosuccinimide to give 4-bromo derivatives I (R1 = H, Me, CPh3; R2 = H, NO2, Me). 2-Nitroimidazole gave dibromo compound II as the only product. I (R1 = CPh3, R2 = H) was treated with BuLi, PrONO2, and HCl to give I (R1 = H, R2 = NO2).
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