Month: January 2022

An article Zirconium-Containing Organic-Inorganic Nanohybrid as a Highly Efficient Catalyst for the Selective Synthesis of Biomass-Derived 2,5-Dihydroxymethylfuran in Isopropanol WOS:000538735600030 published article about TRANSFER HYDROGENATION; LEVULINIC ACID; ELECTROCATALYTIC HYDROGENATION; REDUCTIVE ETHERIFICATION; FURFURYL ALCOHOL; CONVERSION; TRANSFORMATION; HMF; 2,5-BIS(HYDROXYMETHYL)FURAN; DERIVATIVES in [Hu, Lei; Liu, Su; Song, Jie; Jiang, Yetao; He, Aiyong; Xu, Jiaxing] Huaiyin Normal Univ, Jiangsu Collaborat Innovat Ctr Reg Modern Agr & E, Sch Chem & Chem Engn, Jiangsu Key Lab Biomass Based Energy & Enzyme Tec, Huaian 223300, Peoples R China in 2020, Cited 82. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. Safety of Pyrazine-2-carboxylic acid

By the simple assembly of zirconium tetrachloride and diethylenetriaminepentaacetic acid (DTPA), a new acid-base bifunctional zirconium-containing organic-inorganic nanohybrid catalyst (Zr-DTPA) was successfully prepared in this work, and then used for the catalytic transfer hydrogenation (CTH) of biomass-derived 5-hydroxymethylfurfural (HMF) into 2,5-dihydroxymethylfuran (DHMF) using isopropanol as the in situ hydrogen donor and reaction solvent. Satisfactorily, 98.7% HMF conversion and 95.2% DHMF yield could be achieved in 4 h at a moderate reaction temperature of 140 degrees C. After systematic studies, this excellent catalytic activity was proved to be mainly ascribed to the synergistic effect of Lewis-acidic sites (Zr4+) and Lewis-basic sites (O2- and N) with higher strengths and contents. Meanwhile, Zr-DTPA could be readily separated by filtration, when it was repeatedly used 5 recycles, its catalytic activity was not obviously changed, demonstrating that Zr-DTPA had good heterogeneity and reusability. More importantly, Zr-DTPA could also be employed to effectively catalyze the CTH of 5-methylfurfural, furfural, levulinic acid, ethyl levulinate and cyclohexanone into the corresponding products with high yields, indicating that it showed a superior universality for the selective hydrogenation of various biomass-derived carbonyl compounds.Graphical Abstract

Safety of Pyrazine-2-carboxylic acid. Welcome to talk about 98-97-5, If you have any questions, you can contact Hu, L; Liu, S; Song, J; Jiang, YT; He, AY; Xu, JX or send Email.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

An article Controllable luminescent behaviors with pyrazine and benzimidazole groups: Syntheses, crystal structures and properties WOS:000505108100018 published article about BIOLOGICAL EVALUATION; ORGANIC FRAMEWORKS; COMPLEXES; ANTICANCER; POLYMERS; DERIVATIVES; COPPER; DRUGS; PHOTOLUMINESCENCE; HETEROCYCLES in [Wang, Yong-Tao; Wu, Yu-Song; Tang, Gui-Mei] Qilu Univ Technol, Shandong Acad Sci, Dept Chem Engn, Jinan 250353, Shandong, Peoples R China in 2019, Cited 103. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. Computed Properties of C5H4N2O2

A set of new salts containing benzimidazole and pyrazine groups, namely, [HPZBI]X-+(-) nH(2)O (X = Cl (n = 1) (1), NO3 (n = 1) (2), ClO4 (n = 0) (3) and H2PO4 (n = 0) (4)) [PZBI = 2-(pyrazin-2-yl)-1H-benzimidazole], were obtained by the reaction of PZBI and a set of inorganic acid, respectively. The emission maxima can be found at 444, 472, 471, 432 and 443 nm for PZBI and its compounds 1-4 in the solid state at room temperature, respectively. Compared with the free PZBI, the emission maxima of compounds 1-4 are obviously blue/red-shifted for 1-4, indicating that the emission maxima are relative to the intermolecular packing distances. Their photoluminescent lifetime and quantum yield are 1.10 ns and 24.5% for 1, 0.99 ns and 26.4% for 2, 0.94 ns and 21.65% for 3, 2.86 ns and 20.57% for 4, respectively. Compounds 1-4 were structurally characterized by X-ray single crystal diffraction, FT-IR, and UV-Vis spectra. Single crystal X-ray diffraction reveals that pi center dot center dot center dot pi packing interactions and a set of hydrogen bonds can be observed. The shortest distances of pi center dot center dot center dot pi stacking interactions are 3.613, 3.534, 3.731 and 3.492 angstrom in compounds 1-4, respectively. Additionally, the thermal stabilities of compounds 1-4 were investigated in detail.

Computed Properties of C5H4N2O2. Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

I found the field of Life Sciences & Biomedicine – Other Topics very interesting. Saw the article Mechanistic analysis of A46V, H57Y, and D129N in pyrazinamidase associated with pyrazinamide resistance published in 2020. Quality Control of Pyrazine-2-carboxylic acid, Reprint Addresses Wei, DQ (corresponding author), Shanghai Jiao Tong Univ, State Key Lab Microbial Metab, Sch Life Sci & Biotechnol, Minist Educ, Shanghai 200240, Peoples R China.; Wei, DQ (corresponding author), Shanghai Jiao Tong Univ, Joint Lab Int Cooperat Metab & Dev Sci, Minist Educ, Shanghai 200240, Peoples R China.; Wei, DQ (corresponding author), Peng Cheng Lab, Vanke Cloud City Phase 1 Bldg 8,Xili St, Shenzhen 518055, Guangdong, Peoples R China.. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid

Pyrazinamide (PZA) is a component of first-line drugs, active against latent Mycobacterium tuberculosis (MTB) isolates. The prodrug is activated into the active form, pyrazinoic acid (POA) via pncA gene-encoded pyrazinamidase (PZase). Mutations in pncA have been reported, most commonly responsible for PZA-resistance in more than 70% of the resistant cases. In our previous study, we detected many mutations in PZase among PZA-resistance MTB isolates including A46V, H71Y, and D129N. The current study was aimed to investigate the molecular mechanism of PZA-resistance behind mutants (MTs) A46V, H71Y, and D129N in comparison with the wild type (WT) through molecular dynamic (MD) simulation. MTB positive samples were subjected to PZA drug susceptibility testing (DST) against critical concentration (100ug/ml). The resistant samples were subjected to pncA sequencing. Thirty-six various mutations have been observed in the coding region of pncA of PZA-resistant isolates (GenBank accession No. MH461111) including A46V, H71Y, and D129N. The post-simulation analysis revealed a significant variation in MTs structural dynamics as compared to the WT. Root means square deviations (RMSD) and Root means square fluctuation (RMSF) has been found in variation between WT and MTs. Folding effect and pocket volume were altered in MTs when compared with WT. Geometric matching supports the effect of mutation A46V, H71Y, and D129N on PZase structure that may have an insight effect on PZase dynamics, making them vulnerable to convert pro-PZA into active form, POA. In conclusion, the current analyses will provide useful information behind PZA-resistance for better management of drug-resistant TB. (C) 2020 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.

Quality Control of Pyrazine-2-carboxylic acid. Welcome to talk about 98-97-5, If you have any questions, you can contact Khan, MT; Chinnasamy, S; Cui, ZL; Irfan, M; Wei, DQ or send Email.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Authors Dumpala, RMR; Boda, A; Kumar, P; Rawat, N; Ali, SM in AMER CHEMICAL SOC published article about MONOCARBOXYLATE-N-OXIDES; LIQUID-LIQUID-EXTRACTION; 2-PYRAZINECARBOXYLIC ACID; THEORETICAL INSIGHTS; LUMINESCENCE; SEPARATION; EUROPIUM(III); EU3+; LANTHANIDES; SELECTIVITY in [Dumpala, Rama Mohana Rao; Rawat, Neetika] Bhabha Atom Res Ctr, Radioanalyt Chem Div, Mumbai 400085, Maharashtra, India; [Boda, Anil; Ali, Sk. Musharaf] Bhabha Atom Res Ctr, Chem Engn Div, Mumbai 400085, Maharashtra, India; [Kumar, Pranaw] Bhabha Atom Res Ctr, Fuel Chem Div, Mumbai 400085, Maharashtra, India in 2019, Cited 52. Safety of Pyrazine-2-carboxylic acid. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5

The denticity, flexibility, and steric hindrance of the ligand are key factors in deciding the mode and number of coordination around a metal ion on complex formation. The thermodynamic aspects of lanthanide complexation with various multidentate ligands provides a significant insight into understand the coordination chemistry of lanthanides in framing the relevant metal organic networks for the applications in biological, biochemical and medical aspects. The pyrazine carboxylic acids are known to form many structurally important complexes and further can form chelates with coordination number of eight for europium in which more water molecules can be knocked out from the primary coordination sphere than demanded by denticity of the ligand. The present studies aimed at ESI-MS characterization and determination of the thermodynamic parameters (log beta, Delta G, Delta H, and Delta S), luminescence properties of europium complexes with pyrazine-2-carboxylate and pyrazine-2,3-dicarboxylate in aqueous solutions by experiment as well as theory. Time resolved luminescence spectroscopy supported by DFT calculations are carried out to optimize the stable geometries of the complexes with various modes of binding and coordination. Furthermore, the thermodynamic parameters estimated theoretically have been used to trace the path of complex formation.

Welcome to talk about 98-97-5, If you have any questions, you can contact Dumpala, RMR; Boda, A; Kumar, P; Rawat, N; Ali, SM or send Email.. Safety of Pyrazine-2-carboxylic acid

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

SDS of cas: 98-97-5. In 2020 J MED CHEM published article about ANTIINFLAMMATORY DRUGS; IMMUNOPROTEASOME; DESIGN; CELLS; RISK in [Bhattarai, Deepak; Lee, Min Jae; Miller, Zachary; Kim, Kyung Bo] Univ Kentucky, Dept Pharmaceut Sci, Lexington, KY 40536 USA; [Baek, Ahruem; Baek, Yu Mi; Kim, Dong-Eun] Konkuk Univ, Dept Biosci & Biotechnol, Seoul 05029, South Korea; [Yeo, In Jun; Hong, Jin Tae] Chungbuk Natl Univ, Coll Pharm, Cheongju 28160, Chungbuk, South Korea; [Lee, Sukyeong] Baylor Coll Med, Verna & Marrs McLean Dept Biochem & Mol Biol, Houston, TX 77030 USA in 2020, Cited 43. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

The immunoproteasome (iP), an inducible proteasome variant harboring three immunosubunits, low molecular mass polypeptide-2 (LMP2), multicatalytic endopeptidase complex subunit-1, and low molecular mass polypeptide-7 (LMP7), is involved in multiple facets of inflammatory responses. We recently reported that YU102, a dual inhibitor of the iP subunit LMP2 and the constitutive proteasome catalytic subunit beta 1, ameliorates cognitive impairments in mouse models of Alzheimer’s disease (AD) independently of amyloid deposits. To investigate whether inhibition of LMP2 is sufficient to improve the cognitive functions of AD mice, here we prepared 37 YU102 analogues and identified a potent LMP2 inhibitor DB-310 (28) (IC50: 80.6 nM) with improved selectivity and permeability in cells overexpressing ABCB1 transporters. We show that DB-310 induces suppression of IL-1 alpha production in microglia cells and improves cognitive functions in the Tg2576 transgenic mouse model of AD. This study supports that inhibition of LMP2 is a promising therapeutic strategy for treatment of AD.

Welcome to talk about 98-97-5, If you have any questions, you can contact Bhattarai, D; Lee, MJ; Baek, A; Yeo, IJ; Miller, Z; Baek, YM; Lee, S; Kim, DE; Hong, JT; Kim, KB or send Email.. SDS of cas: 98-97-5

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

SDS of cas: 98-97-5. In 2019 J AM CHEM SOC published article about TERTIARY BORONIC ESTERS; AMINOBORONIC ACID-DERIVATIVES; ASYMMETRIC HYDROBORATION; PINACOLBORYL ADDITION; AMINOBORATION; ALKENES; SECONDARY; HYDROFUNCTIONALIZATION; HYDROALKYNYLATION; BORYLATION in [Bai, Xiao-Yan; Zhao, Wei; Sun, Xin; Li, Bi-Jie] Tsinghua Univ, Dept Chem, CBMS, Beijing 100084, Peoples R China in 2019, Cited 89. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

Chiral alpha- and beta-aminoboronic acids exhibit unique biological activities. General methods for the synthesis of these bioisosteres of amino acids are highly desirable. We report a facile preparation of these compounds through rhodium-catalyzed regiodivergent and enantioselective hydroboration of enamides. Catalytic asymmetric synthesis of alpha- and beta-aminoboronic esters with high regio-, diastereo-, and enantioselectivities were achieved through effective catalyst control and tuning substrate geometry. Starting from easily available materials, this strategy provides a unified synthetic access to both enantioenriched alpha-boration and beta-boration products. The synthetic utility of these methods was demonstrated by efficient synthesis of an anticancer drug molecule and diverse transformations of the boration products.

Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 98-97-5

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Yao, H; Xie, SW; Ma, XQ; Liu, JK; Wu, HY; Lin, AJ; Yao, HQ; Li, DH; Xu, ST; Yang, DH; Chen, ZS; Xu, JY in [Yao, Hong; Xie, Shaowen; Ma, Xiaoqian; Liu, Junkai; Wu, Hongyu; Lin, Aijun; Yao, Hequan; Xu, Shengtao; Xu, Jinyi] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Peoples R China; [Yao, Hong; Xie, Shaowen; Ma, Xiaoqian; Liu, Junkai; Wu, Hongyu; Lin, Aijun; Yao, Hequan; Xu, Shengtao; Xu, Jinyi] China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Peoples R China; [Li, Dahong] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Key Lab Struct Based Drug Design & Discovery, Minist Educ, Shenyang 110016, Peoples R China; [Yang, Dong-Hua; Chen, Zhe-Sheng] St Johns Univ, Coll Pharm & Hlth Sci, Queens, NY 11439 USA published Identification of a Potent Oridonin Analogue for Treatment of Triple-Negative Breast Cancer in 2020, Cited 46. COA of Formula: C5H4N2O2. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

Triple-negative breast cancer (TNBC) is one of the most highly invasive and metastatic breast cancers without safe and effective therapeutic drugs. The natural product oridonin is reported to be a potential anti-TNBC agent. However, its moderate activity and complex structure hampered its clinical application. In this study, the novel oridonin analogues were first identified by removal of multiple hydroxyl groups and structural simplification of oridonin. The representative analogue 20 exhibited potent anticancer effects. Further structural modification on 20 generated the most potent derivative 56, which possessed 120-fold more potent antiproliferative activity than oridonin in the TNBC cell line HCC1806. Importantly, compound 56 exhibited more potent anticancer activity than paclitaxel in TNBC xenograft nude mice. Moreover, 56 could attenuate the expression of MMP-2, MMP-9, p-FAK, and integrin beta 1 to inhibit TNBC cell metastasis. All results suggest that compound 56 may warrant further investigation as a promising candidate agent for the treatment of TNBC.

Welcome to talk about 98-97-5, If you have any questions, you can contact Yao, H; Xie, SW; Ma, XQ; Liu, JK; Wu, HY; Lin, AJ; Yao, HQ; Li, DH; Xu, ST; Yang, DH; Chen, ZS; Xu, JY or send Email.. COA of Formula: C5H4N2O2

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Reddyrajula, R; Dalimba, U in [Reddyrajula, Rajkumar; Dalimba, Udayakumar] Natl Inst Technol Karnataka, Dept Chem, Organ Chem Lab, Mangalore 575025, India published The bioisosteric modification of pyrazinamide derivatives led to potent antitubercular agents: Synthesis via click approach and molecular docking of pyrazine-1,2,3-triazoles in 2020, Cited 38. SDS of cas: 98-97-5. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

Tuberculosis remains as a major public health risk which causes the highest mortality rate globally and an improved regimen is required to treat the drug-resistant strains. Pyrazinamide is a first-line antitubercular drug used in combination therapy with other anti-TB drugs. Herein, we describe the modification of pyrazinamide structure using bioisosterism and rational approaches by incorporating the 1,2,3-triazole moiety. Three sets of pyrazine-1,2,3-triazoles (3a-o, 5a-o and 9a-l) are designed, synthesized and evaluated for their in vitro inhibitory potency against mycobacterium tuberculosis H(37)Rv. The pyrazine-1,2,3-triazoles synthesized through the bioisosteric modification displayed improved activity as compared to rationally modified pyrazine-1,2,3-triazoles. Among 42 title compounds, seven derivatives demonstrated significant anti-tubercular activity with the MIC of 1.56 mu g/mL, which are two-fold more potent than the parent compound pyrazinamide. Further, the synthesized pyrazinamide analogs demonstrated moderate inhibition activity against several bacterial strains and possessed an acceptable in vitro cytotoxicity profile as well. Additionally, the activity profile of pyrazine-1,2,3-triazoles was validated by performing the molecular docking studies against the Inh A enzyme. Furthermore, in silico ADME prediction revealed good oral bioavailability for the potent molecules.

Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 98-97-5

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Product Details of 98-97-5. In 2020 DRUG DELIV published article about ANTITUMOR-ACTIVITY; QUINOXALINE DERIVATIVES; THIOPHENE DERIVATIVES; CRYSTAL-STRUCTURE; TUMOR-CELLS; ANTICANCER; CYTOTOXICITY; COPPER(II); INHIBITORS; COMPLEXES in [Zhao, Fengyi; Xu, Li; Cao, Fuliang] Nanjing Forestry Univ, Coinnovat Ctr Sustainable Forestry Southern China, Nanjing 210037, Peoples R China; [Zhao, Fengyi; Cao, Fuliang] Nanjing Forestry Univ, Coll Forestry, Nanjing, Peoples R China; [Zhao, Fengyi; Sun, Xu; Lu, Wen; Xu, Li; Shi, Jiuzhou] Nanjing Forestry Univ, Coll Sci, Nanjing, Peoples R China; [Sun, Xu] Nanjing Forestry Univ, Coll Informat Sci & Technol, Nanjing, Peoples R China; [Yang, Shilong; Zhou, Mengyi; Su, Fan; Lin, Feng] Nanjing Forestry Univ, Adv Anal & Testing Ctr, Nanjing, Peoples R China in 2020, Cited 60. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

Several dehydroabietylamine derivatives containing heterocyclic moieties such as thiophene and pyrazine ring were successfully synthesized. The antiproliferative activities of these thiophene-based Schiff-bases, thiophene amides, and pyrazine amides were investigated in vitro against Hela (cervix), MCF-7 (breast), A549 (lung), HepG2 (liver), and HUVEC (umbilical vein) cells by MTT assay. The toxicity of L-1-L-10 (IC50 = 5.92- >100 mu M) was lower than L-0 (1.27 mu M) and DOX (4.40 mu M) in every case. Compound L-1 had higher anti-HepG2 (0.66 mu M), anti-MCF-7 (5.33 mu M), and anti-A549 (2.11 mu M) and compound L-3 had higher anti-HepG2 (1.63 mu M) and anti-MCF-7 (2.65 mu M) activities. Both of these compounds were recognized with high efficiency in apoptosis induction in HepG2 cells and intercalated binding modes with DNA. Moreover, with average IC50 values of 0.66 and 5.98 mu M, L-1 was nine times more effective at suppressing cultured HepG2 cells viability than normal cells (SI = 9). The relative tumor proliferation rate (T/C) was 38.6%, the tumor inhibition rate was up to 61.2%, which indicated that L-1 had no significant toxicity but high anti-HepG2 activity in vivo. Thus, it may be a potential antiproliferation drug with nontoxic side effects.

Product Details of 98-97-5. Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In 2020 CRYST GROWTH DES published article about HALIDE ION SYNTHON; CRYSTAL-STRUCTURES; INTERMOLECULAR INTERACTIONS; HYDROGEN-BONDS; MOLECULES; HIERARCHY; CROSSOVER; LIGANDS; METALS; BR in [Khavasi, Hamid Reza; Gholami, Akram; Hosseini, Mahdieh; Nikpoor, Leyla] Shahid Beheshti Univ, Dept Inorgan Chem & Catalysis, Tehran 1983963113, Iran; [Eskandari, Kiamars] Isfahan Univ Technol, Dept Chem, Esfahan 8415683111, Iran in 2020, Cited 45. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. Name: Pyrazine-2-carboxylic acid

A family of 10 compounds, each containing a MX2-pyrazine carboxylate complex anion and a protonated halo- (X’-) amino pyridine cation (MX2 = ZnCl2, ZnBr2, ZnI2, HgBr2, and HgI2; X’ = Cl, Br, I), are presented; a suitable system for pursuing C-X’center dot center dot center dot X-M halogen bonding (XB). The influence of halogen manipulation, metal ion and coordination variation on the nature and strength of C-X’center dot center dot center dot X-M interactions was discussed in terms of geometrical parameters, binding energies and charge density analysis with emphasis on the Laplacian of the electron density, del(2)rho. Interplay of XBs with other noncovalent interactions, mainly N-H center dot center dot center dot XM and N-py-H+center dot center dot center dot O- bonds, in supramolecular assemblies, were also investigated. The C-X’center dot center dot center dot X-M and N-H center dot center dot center dot X-M bonds have rationally been modified in strength upon changing the halogens involved, leading to systematic variations in the crystal packing.

Welcome to talk about 98-97-5, If you have any questions, you can contact Khavasi, HR; Gholami, A; Hosseini, M; Nikpoor, L; Eskandari, K or send Email.. Name: Pyrazine-2-carboxylic acid

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem