Safety of Pyrazine-2-carboxylic acid. Recently I am researching about PHASE-II TRIAL; ORGANIC SULFUR CHEMISTRY; QUINOXALINE ANTIBIOTICS; TRIOSTIN; HYPOXIA; DESULFURIZATION; DEPSIPEPTIDES; QUINOMYCIN; PATHWAY, Saw an article supported by the JSPSMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of Science [16H05097, 19H03345, 18H04599, 20H04757]; Hokkaido University, Global Facility Center (GFC), Pharma Science Open Unit (PSOU) – MEXT under Support Program for Implementation of New Equipment Sharing System, Platform Project for Supporting Drug Discovery and Life Science Research (Basis for Suppor [18am0101093j0002]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Kojima, K; Yakushiji, F; Katsuyama, A; Ichikawa, S. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid
The first total synthesis of echinomycin (1) was accomplished by featuring the late-stage construction of the thioacetal moiety via Pummerer rearrangement and simultaneous cyclization, as well as two-directional elongation of the peptide chains to construct a C2-symmetrical bicyclic octadecadepsipeptide bridged with a sulfide linkage. This strategy can be applicable to a variety of echinomycin analogues.
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Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem