Final Thoughts on Chemistry for 98-97-5

Quality Control of Pyrazine-2-carboxylic acid. Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.

An article Calculation of the Isobaric Heat Capacities of the Liquid and Solid Phase of Organic Compounds at and around 298.15 K Based on Their True Molecular Volume WOS:000467765700181 published article about STANDARD MOLAR ENTHALPY; STRUCTURE-PROPERTY RELATIONSHIPS; THERMODYNAMIC PROPERTIES; IONIC LIQUIDS; THERMOPHYSICAL PROPERTIES; TEMPERATURE-RANGE; GROUP ADDITIVITY; VAPOR-PRESSURES; THERMAL-ANALYSIS; COMPUTATIONAL THERMOCHEMISTRY in [Naef, Rudolf] Univ Basel, Dept Chem, CH-4003 Basel, Switzerland in 2019, Cited 287. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. Quality Control of Pyrazine-2-carboxylic acid

A universally applicable method for the prediction of the isobaric heat capacities of the liquid and solid phase of molecules at 298.15 K is presented, derived from their true volume. The molecules’ true volume in A(3) is calculated on the basis of their geometry-optimized structure and the Van-der-Waals radii of their constituting atoms by means of a fast numerical algorithm. Good linear correlations of the true volume of a large number of compounds encompassing all classes and sizes with their experimental liquid and solid heat capacities over a large range have been found, although noticeably distorted by intermolecular hydrogen-bond effects. To account for these effects, the total amount of 1303 compounds with known experimental liquid heat capacities has been subdivided into three subsets consisting of 1102 hydroxy-group-free compounds, 164 monoalcohols/monoacids, and 36 polyalcohols/polyacids. The standard deviations for Cp(liq,298) were 20.7 J/mol/K for the OH-free compunds, 22.91 J/mol/K for the monoalcohols/monoacids and 16.03 J/mol/K for the polyols/polyacids. Analogously, 797 compounds with known solid heat capacities have been separated into a subset of 555 OH-free compounds, 123 monoalcohols/monoacids and 119 polyols/polyacids. The standard deviations for Cp(sol,298) were calculated to 23.14 J/mol/K for the first, 21.62 J/mol/K for the second, and 19.75 J/mol/K for the last subset. A discussion of structural and intermolecular effects influencing the heat capacities as well as of some special classes, in particular hydrocarbons, ionic liquids, siloxanes and metallocenes, has been given. In addition, the present method has successfully been extended to enable the prediction of the temperature dependence of the solid and liquid heat capacities in the range between 250 and 350 K.

Quality Control of Pyrazine-2-carboxylic acid. Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Let`s talk about compound :Pyrazine-2-carboxylic acid

Welcome to talk about 98-97-5, If you have any questions, you can contact Li, S; Zhao, JA; Guo, Y; Mei, YM; Yuan, BP; Gan, N; Zhang, JS; Hu, JY; Hou, HW or send Email.. Recommanded Product: Pyrazine-2-carboxylic acid

In 2020 J INORG BIOCHEM published article about IN-VITRO; MITOCHONDRIAL; CISPLATIN; DNA; LIGANDS; CYTOTOXICITY; MECHANISMS; CRYSTAL; DAMAGE; CELLS in [Zhao, Jin’an; Guo, Yan; Gan, Ning; Zhang, Junshuai; Hu, Jiyong] Henan Univ Urban Construct, Coll Mat & Chem Engn, Pingdingshan 467036, Henan, Peoples R China; [Li, Sen; Mei, Yameng; Yuan, Bangpeng; Hou, Hongwei] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Henan, Peoples R China in 2020, Cited 43. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. Recommanded Product: Pyrazine-2-carboxylic acid

Aiming at obtaining new copper complexes with good cytotoxicity against cancer cells, triphenylphosphine (TPP) was introduced to obtain insight into the influence of the co-ligands. In this paper, two copper complexes, Cu(2-pbmq)(CH3OH)Br-2 (1) and [Cu(2-pbmq)(TPP)Br](2) (2) were designed, synthesized, and characterized by X-ray crystallography, 2-((2-(pyrazin-2-yl)-1H-benzo[d]imidazol-1-yl)methyl))quinolone (2-pbmq), to investigate the influence of the TPP group on the anticancer activity of the metal complex. Although the presence of the TPP group diminished the intensity of the interaction properties of the complex with DNA, the in vitro anticancer activity and cellular uptake of the TPP-containing complex were markedly superior to those of its TPP-lacking counterpart. Detailed studies on the more potently cytotoxic complex 2 revealed that it accumulated in nucleus, arrested the cell cycle at the G0-G1 phase, causing mitochondrial dysfunction, involving the potential simultaneous mitochondrial membrane collapse, cellular ATP level depletion, and Ca2+ leakage, eventually inducing cell apoptosis. In summary, the introduction of a TPP group enhances the biological activity and cytotoxicity of the complex.

Welcome to talk about 98-97-5, If you have any questions, you can contact Li, S; Zhao, JA; Guo, Y; Mei, YM; Yuan, BP; Gan, N; Zhang, JS; Hu, JY; Hou, HW or send Email.. Recommanded Product: Pyrazine-2-carboxylic acid

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Let`s talk about compound :98-97-5

Welcome to talk about 98-97-5, If you have any questions, you can contact Wang, YT; Wu, YS; Tang, GM or send Email.. HPLC of Formula: C5H4N2O2

An article Controllable luminescent behaviors with pyrazine and benzimidazole groups: Syntheses, crystal structures and properties WOS:000505108100018 published article about BIOLOGICAL EVALUATION; ORGANIC FRAMEWORKS; COMPLEXES; ANTICANCER; POLYMERS; DERIVATIVES; COPPER; DRUGS; PHOTOLUMINESCENCE; HETEROCYCLES in [Wang, Yong-Tao; Wu, Yu-Song; Tang, Gui-Mei] Qilu Univ Technol, Shandong Acad Sci, Dept Chem Engn, Jinan 250353, Shandong, Peoples R China in 2019, Cited 103. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. HPLC of Formula: C5H4N2O2

A set of new salts containing benzimidazole and pyrazine groups, namely, [HPZBI]X-+(-) nH(2)O (X = Cl (n = 1) (1), NO3 (n = 1) (2), ClO4 (n = 0) (3) and H2PO4 (n = 0) (4)) [PZBI = 2-(pyrazin-2-yl)-1H-benzimidazole], were obtained by the reaction of PZBI and a set of inorganic acid, respectively. The emission maxima can be found at 444, 472, 471, 432 and 443 nm for PZBI and its compounds 1-4 in the solid state at room temperature, respectively. Compared with the free PZBI, the emission maxima of compounds 1-4 are obviously blue/red-shifted for 1-4, indicating that the emission maxima are relative to the intermolecular packing distances. Their photoluminescent lifetime and quantum yield are 1.10 ns and 24.5% for 1, 0.99 ns and 26.4% for 2, 0.94 ns and 21.65% for 3, 2.86 ns and 20.57% for 4, respectively. Compounds 1-4 were structurally characterized by X-ray single crystal diffraction, FT-IR, and UV-Vis spectra. Single crystal X-ray diffraction reveals that pi center dot center dot center dot pi packing interactions and a set of hydrogen bonds can be observed. The shortest distances of pi center dot center dot center dot pi stacking interactions are 3.613, 3.534, 3.731 and 3.492 angstrom in compounds 1-4, respectively. Additionally, the thermal stabilities of compounds 1-4 were investigated in detail.

Welcome to talk about 98-97-5, If you have any questions, you can contact Wang, YT; Wu, YS; Tang, GM or send Email.. HPLC of Formula: C5H4N2O2

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Archives for Chemistry Experiments of Pyrazine-2-carboxylic acid

COA of Formula: C5H4N2O2. Welcome to talk about 98-97-5, If you have any questions, you can contact Yang, YJ; Wang, K; Yang, Y; Lai, FF; Chen, XG; Xiao, ZY or send Email.

COA of Formula: C5H4N2O2. Authors Yang, YJ; Wang, K; Yang, Y; Lai, FF; Chen, XG; Xiao, ZY in TAYLOR & FRANCIS LTD published article about in [Yang, Ya-Jun; Wang, Ke; Yang, Ying; Xiao, Zhi-Yan] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing Key Lab Active Subst Discovery & Druggabi, Beijing 100050, Peoples R China; [Lai, Fang-Fang; Chen, Xiao-Guang] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China in 2021, Cited 21. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5

Based on the interaction modes of the natural 20S proteasome inhibitors TMC-95A, we have previously discovered a dipeptide 1. To explore the SAR around compound 1, we designed and synthesized a series of dipeptides (8-38) with a fragment-based strategy. Among them, nine compounds showed significant inhibitory activities against the chymotrypsin-like activity of human 20S proteasome with IC50 values at the submicromolar level, which were comparable or even superior to the parent compound 1. Meanwhile, they displayed no significant inhibition against trypsin-like and caspase-like activities of 20S proteasome. The results suggested the feasibility to design dipeptides as novel and potent 20S proteasome inhibitors.

COA of Formula: C5H4N2O2. Welcome to talk about 98-97-5, If you have any questions, you can contact Yang, YJ; Wang, K; Yang, Y; Lai, FF; Chen, XG; Xiao, ZY or send Email.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Properties and Exciting Facts About 98-97-5

Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.. Name: Pyrazine-2-carboxylic acid

Recently I am researching about MYCOBACTERIUM-TUBERCULOSIS; CATALASE-PEROXIDASE; SUSCEPTIBILITY; ARTEMISININ; ANTIMALARIAL; RESISTANCE; KATG, Saw an article supported by the CSIR Thematic Program Fund; South African Medical Research CouncilUK Research & Innovation (UKRI)Medical Research Council UK (MRC) [MRC-RFA-UFSP-01-2013]; SAMRCUK Research & Innovation (UKRI)Medical Research Council UK (MRC). Name: Pyrazine-2-carboxylic acid. Published in BENTHAM SCIENCE PUBL LTD in SHARJAH ,Authors: van der Westhuyzen, CW; Haynes, RK; Panayides, JL; Wiid, I; Parkinson, CJ. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid

Background: With few exceptions, existing tuberculosis drugs were developed many years ago and resistance profiles have emerged. This has created a need for new drugs with discrete modes of action. There is evidence that tuberculosis (like other bacteria) is susceptible to oxidative pressure and this has yet to be properly utilised as a therapeutic approach in a manner similar to that which has proven highly successful in malaria therapy. Objective: To develop an alternative approach to the incorporation of bacterial siderophores that results in the creation of antitubercular peroxidic leads for subsequent development as novel agents against tuberculosis. Methods: Eight novel peroxides were prepared and the antitubercular activity (H(37)Rv) was compared to existing artemisinin derivatives in vitro. The potential for toxicity was evaluated against the L6 rat skeletal myoblast and HeLa cervical cancer lines in vitro. Results: The addition of a pyrimidinyl residue to an artemisinin or, preferably, a tetraoxane peroxidic structure results in antitubercular activity in vitro. The same effect is not observed in the absence of the pyrimidine or with other heteroaromatic substituents. Conclusion: The incorporation of a pyrimidinyl residue adjacent to the peroxidic function in an organic peroxide results in anti-tubercular activity in an otherwise inactive peroxidic compound. This will be a useful approach for creating oxidative drugs to target tuberculosis.

Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.. Name: Pyrazine-2-carboxylic acid

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

What about chemistry interests you the most 98-97-5

Application In Synthesis of Pyrazine-2-carboxylic acid. Welcome to talk about 98-97-5, If you have any questions, you can contact de Almeida, AC; Ferreira, PO; Torquetti, C; Ekawa, B; Carvalho, ACS; dos Santos, EC; Caires, F or send Email.

Authors de Almeida, AC; Ferreira, PO; Torquetti, C; Ekawa, B; Carvalho, ACS; dos Santos, EC; Caires, F in SPRINGER published article about PHARMACEUTICAL COCRYSTALS; SALTS; DESIGN; POLYMORPHISM; INVESTIGATE; SOLUBILITY; STABILITY; BEHAVIOR; COFORMER; LIQUID in [de Almeida, Amanda Cosmo; Ferreira, Patricia Osorio; Ekawa, Bruno; Sobral Carvalho, Ana Carina; Caires, Flavio Junior] Sao Paulo State Univ, Inst Chem, UNESP, Araraquara, Brazil; [Torquetti, Carolina; dos Santos, Everton Carvalho; Caires, Flavio Junior] Sao Paulo State Univ, Sch Sci, UNESP, Bauru, Brazil in 2020, Cited 52. Application In Synthesis of Pyrazine-2-carboxylic acid. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5

Novel cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic acid in the 1:1 stoichiometric ratio were obtained by the mechanochemical method, under conditions of liquid-assisted grinding (LAG/ethanol) and neat grinding. They were characterized by powder X-ray diffractometry, infrared spectroscopy, simultaneous thermogravimetry, differential thermal analysis, differential scanning calorimetry (DSC) and DSC-Microscopy system. The results confirmed the successful synthesis of the cocrystals and indicated the functional groups responsible for the formation of the new supramolecular synthons. In addition, from the thermal analysis, it was possible to evaluate the thermal stability, composition, crystallization processes during heating, polymorphic transitions and construct the binary phase diagrams.

Application In Synthesis of Pyrazine-2-carboxylic acid. Welcome to talk about 98-97-5, If you have any questions, you can contact de Almeida, AC; Ferreira, PO; Torquetti, C; Ekawa, B; Carvalho, ACS; dos Santos, EC; Caires, F or send Email.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

What advice would you give a new faculty member or graduate student interested in a career Pyrazine-2-carboxylic acid

Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.. Product Details of 98-97-5

Product Details of 98-97-5. In 2019 J MOL STRUCT published article about AB-INITIO CALCULATIONS; SPECTROSCOPIC FT-IR; MOLECULAR DOCKING; VIBRATIONAL-SPECTRA; DNA-BINDING; CRYSTAL-STRUCTURE; DFT CALCULATIONS; DISPERSE DYES; MYCOBACTERIUM-TUBERCULOSIS; ANTIMICROBIAL PROPERTIES in [Maliyappa, M. R.; Keshavayya, J.; Mallikarjuna, N. M.] Kuvempu Univ, Dept PG Studies & Res Chem, Shimoga 577451, Karnataka, India; [Krishna, P. Murali; Shivakumara, N.] MS Ramaiah Inst Technol, Dept Chem, Bengaluru 560054, India; [Sandeep, Telkar] Kuvempu Univ, Dept PG Studies & Res Biotechnol & Bioinformat, Shimoga 577451, Karnataka, India; [Sailaja, Krishnamurty] Natl Chem Lab, Phys & Mat Chem Div, Pune 411008, Maharashtra, India; [Nazrulla, Mohammed Azeezulla] CSIR Cent Electrochem Res Inst, Funct Mat Div, Karaikkudi 630006, Tamil Nadu, India in 2019, Cited 82. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

The present work describes the synthesis of five novel heterocyclic azo dyes (4a-4e) through conventional diazo-coupling reaction of 4, 5, 6, 7-tetrahydro-1, 3-benzothiazole with various coupling compounds at 0-5 degrees C. The chemical structures of the synthesized azo dyes were characterized by both theoretical and experimental techniques. All the synthesized molecules were evaluated for their antioxidant activity by two different techniques such as DPPH and FRAP. The results indicated that all the synthesized compounds proved to be potent antioxidants. The anti-mycobacterial activity of the azo dyes was tested against M. tuberculosis and the compounds 4a and 4e showed higher activity among the tested dyes. The DNA binding studies showed effective intercalation properties between the azo dyes and CT-DNA. Finally, the molecular docking studies indicated a possible interaction of the azo dyes with target receptor RpsA. (C) 2018 Elsevier B.V. All rights reserved.

Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.. Product Details of 98-97-5

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

What kind of challenge would you like to see in a future of compound:C5H4N2O2

Computed Properties of C5H4N2O2. Welcome to talk about 98-97-5, If you have any questions, you can contact Li, S; Zhao, JA; Guo, Y; Mei, YM; Yuan, BP; Gan, N; Zhang, JS; Hu, JY; Hou, HW or send Email.

Recently I am researching about IN-VITRO; MITOCHONDRIAL; CISPLATIN; DNA; LIGANDS; CYTOTOXICITY; MECHANISMS; CRYSTAL; DAMAGE; CELLS, Saw an article supported by the Key Scientific Research Project of Colleges and Universities in Henan Province [19A150017]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21371046, 21401041]; Funding Program for Academic Technology Leaders of the He’nan University of Urban Construction [YCJXSJSDTR201705]. Published in ELSEVIER SCIENCE INC in NEW YORK ,Authors: Li, S; Zhao, JA; Guo, Y; Mei, YM; Yuan, BP; Gan, N; Zhang, JS; Hu, JY; Hou, HW. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid. Computed Properties of C5H4N2O2

Aiming at obtaining new copper complexes with good cytotoxicity against cancer cells, triphenylphosphine (TPP) was introduced to obtain insight into the influence of the co-ligands. In this paper, two copper complexes, Cu(2-pbmq)(CH3OH)Br-2 (1) and [Cu(2-pbmq)(TPP)Br](2) (2) were designed, synthesized, and characterized by X-ray crystallography, 2-((2-(pyrazin-2-yl)-1H-benzo[d]imidazol-1-yl)methyl))quinolone (2-pbmq), to investigate the influence of the TPP group on the anticancer activity of the metal complex. Although the presence of the TPP group diminished the intensity of the interaction properties of the complex with DNA, the in vitro anticancer activity and cellular uptake of the TPP-containing complex were markedly superior to those of its TPP-lacking counterpart. Detailed studies on the more potently cytotoxic complex 2 revealed that it accumulated in nucleus, arrested the cell cycle at the G0-G1 phase, causing mitochondrial dysfunction, involving the potential simultaneous mitochondrial membrane collapse, cellular ATP level depletion, and Ca2+ leakage, eventually inducing cell apoptosis. In summary, the introduction of a TPP group enhances the biological activity and cytotoxicity of the complex.

Computed Properties of C5H4N2O2. Welcome to talk about 98-97-5, If you have any questions, you can contact Li, S; Zhao, JA; Guo, Y; Mei, YM; Yuan, BP; Gan, N; Zhang, JS; Hu, JY; Hou, HW or send Email.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Final Thoughts on Chemistry for Pyrazine-2-carboxylic acid

Name: Pyrazine-2-carboxylic acid. Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.

An article Spectroscopic and Theoretical Investigation of Color Tuning in Deep-Red Luminescent Iridium(III) Complexes WOS:000514488400018 published article about HIGHLY EFFICIENT; METAL-COMPLEXES; QUINOXALINE LIGANDS; 1ST EXAMPLES; PHOSPHORESCENT; EMISSION; BEARING; PHOTOPHYSICS; CONVERSION; DEVICES in [Stonelake, Thomas M.; Phillips, Kaitlin A.; Otaif, Haleema Y.; Edwardson, Zachary C.; Beames, Joseph M.; Pope, Simon J. A.] Cardiff Univ, Sch Chem, Cardiff CF10 3AT, Wales; [Horton, Peter N.; Coles, Simon J.] Univ Southampton, Fac Nat & Environm Sci, UK Natl Crystallog Serv, Chem, Southampton SO17 1BJ, Hants, England in 2020, Cited 60. Name: Pyrazine-2-carboxylic acid. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5

A series of heteroleptic, neutral iridium(III) complexes of the form [Ir(L)(2)(N boolean AND O)] (where L = cyclometalated 2,3-disubstituted quinoxaline and N boolean AND O = ancillary picolinate or pyrazinoate) are described in terms of their synthesis and spectroscopic properties, with supporting computational analyses providing additional insight into the electronic. properties. The 10 [Ir(L)(2)(N boolean AND O)] complexes were characterized using a range of analytical techniques (including H-1, C-13, and F-19 NMR and IR spectroscopies and mass spectrometry). One of the examples was structurally characterized using X-ray diffraction. The redox properties were determined using cyclic voltammetry, and the electronic properties were investigated using UV-vis, time-resolved luminescence, and transient absorption spectroscopies. The complexes are phosphorescent in the red region of the visible spectrum (lambda(em) = 633-680 nm), with lifetimes typically of hundreds of nanoseconds and quantum yields ca. 5% in aerated chloroform. A combination of spectroscopic and computational analyses suggests that the long-wavelength absorption and emission properties of these complexes are strongly characterized by a combination of spin-forbidden metal-to-ligand charge-transfer and quinoxaline-centered transitions. The emission wavelength in these complexes can thus be controlled in two ways: first, substitution of the cyclometalating quinoxaline ligand can perturb both the highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital levels (LUMO, Cl atoms on the ligand induce the largest bathochromic shift), and second, the choice of the ancillary ligand can influence the HOMO energy (pyrazinoate stabilizes the HOMO, inducing hypsochromic shifts).

Name: Pyrazine-2-carboxylic acid. Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Let`s talk about compound :C5H4N2O2

Application In Synthesis of Pyrazine-2-carboxylic acid. Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.

Application In Synthesis of Pyrazine-2-carboxylic acid. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Pentacyanoferrate(II) complex of pyridine-4-and pyrazine-2-hydroxamic acid as source of HNO: investigation of anti-tubercular and vasodilation activities published in 2020, Reprint Addresses Bernardes-Genisson, V (corresponding author), CNRS, Lab Chim Coordinat, LCC, UPR 8241, 205 Route Narbonne,BP 44099, F-31077 Toulouse 4, France.; Bernardes-Genisson, V (corresponding author), Univ Toulouse, Univ Paul Sabatier, UPS, 118 Route Narbonne, F-31062 Toulouse 9, France.; Sousa, EHS (corresponding author), Univ Fed Ceara, Dept Quim Organ & Inorgan, Grp Bioinorgen, Campus Pici, BR-60455760 Fortaleza, Ceara, Brazil.; Sousa, EHS (corresponding author), Inst Nacl Ciencia & Tecnol TB INCT TB, Porto Alegre, RS, Brazil.. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid.

A pharmacophore design approach, based on the coordination chemistry of an intimate molecular hybrid of active metabolites of pro-drugs, known to release active species upon enzymatic oxidative activation, is devised. This is exemplified by combining two anti-mycobacterial drugs: pyrazinamide (first line) and delamanid (third line) whose active metabolites are pyrazinoic acid (PyzCOOH) and likely nitroxyl (HNO (or NO.)), respectively. Aiming to generate those active species, a hybrid compound was envisaged by coordination of pyrazine-2-hydroxamic acid (PyzCONHOH) with a Na-3[Fe-II(CN)(5)] moiety. The corresponding pentacyanoferrate(II) complex Na-4[Fe-II(CN)(5)(PyzCONHO(-))] was synthesized and characterized by several spectroscopic techniques, cyclic voltammetry, and DFT calculations. Chemical oxidation of this complex with H(2)O(2)was shown to induce the release of the metabolite PyzCOOH, without the need of theMycobacterium tuberculosis(Mtb) pyrazinamidase enzyme (PncA). Control experiments show that both H2O2- and N-coordinated pyrazine Fe(II)species are required, ruling out a direct hydrolysis of the hydroxamic acid or an alternative oxidative route through chelation of a metal center by a hydroxamic group. The release of HNO was observed using EPR spectroscopy in the presence of a spin trapping agent. The devised iron metal complex of pyrazine-2-hydroxamic acid was found inactive against an actively growing/non-resistantMtbstrain; however, it showed a strong dose-dependent and reversible vasodilatory activity with mostly lesser toxic effects than the reference drug sodium nitroprussiate, unveiling thus a potential indication for acute or chronic cardiovascular pathology. This is a priori a further indirect evidence of HNO release from this metal complex, standing as a possible pharmacophore model for an alternative vasodilator drug.

Application In Synthesis of Pyrazine-2-carboxylic acid. Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem