Month: November 2021

de Almeida, AC; Ferreira, PO; Torquetti, C; Ekawa, B; Carvalho, ACS; dos Santos, EC; Caires, F in [de Almeida, Amanda Cosmo; Ferreira, Patricia Osorio; Ekawa, Bruno; Sobral Carvalho, Ana Carina; Caires, Flavio Junior] Sao Paulo State Univ, Inst Chem, UNESP, Araraquara, Brazil; [Torquetti, Carolina; dos Santos, Everton Carvalho; Caires, Flavio Junior] Sao Paulo State Univ, Sch Sci, UNESP, Bauru, Brazil published Mechanochemical synthesis, characterization and thermal study of new cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic acid in 2020, Cited 52. Recommanded Product: 98-97-5. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

Novel cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic acid in the 1:1 stoichiometric ratio were obtained by the mechanochemical method, under conditions of liquid-assisted grinding (LAG/ethanol) and neat grinding. They were characterized by powder X-ray diffractometry, infrared spectroscopy, simultaneous thermogravimetry, differential thermal analysis, differential scanning calorimetry (DSC) and DSC-Microscopy system. The results confirmed the successful synthesis of the cocrystals and indicated the functional groups responsible for the formation of the new supramolecular synthons. In addition, from the thermal analysis, it was possible to evaluate the thermal stability, composition, crystallization processes during heating, polymorphic transitions and construct the binary phase diagrams.

Welcome to talk about 98-97-5, If you have any questions, you can contact de Almeida, AC; Ferreira, PO; Torquetti, C; Ekawa, B; Carvalho, ACS; dos Santos, EC; Caires, F or send Email.. Recommanded Product: 98-97-5

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Recommanded Product: Pyrazine-2-carboxylic acid. In 2019 J AM CHEM SOC published article about TERTIARY BORONIC ESTERS; AMINOBORONIC ACID-DERIVATIVES; ASYMMETRIC HYDROBORATION; PINACOLBORYL ADDITION; AMINOBORATION; ALKENES; SECONDARY; HYDROFUNCTIONALIZATION; HYDROALKYNYLATION; BORYLATION in [Bai, Xiao-Yan; Zhao, Wei; Sun, Xin; Li, Bi-Jie] Tsinghua Univ, Dept Chem, CBMS, Beijing 100084, Peoples R China in 2019, Cited 89. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

Chiral alpha- and beta-aminoboronic acids exhibit unique biological activities. General methods for the synthesis of these bioisosteres of amino acids are highly desirable. We report a facile preparation of these compounds through rhodium-catalyzed regiodivergent and enantioselective hydroboration of enamides. Catalytic asymmetric synthesis of alpha- and beta-aminoboronic esters with high regio-, diastereo-, and enantioselectivities were achieved through effective catalyst control and tuning substrate geometry. Starting from easily available materials, this strategy provides a unified synthetic access to both enantioenriched alpha-boration and beta-boration products. The synthetic utility of these methods was demonstrated by efficient synthesis of an anticancer drug molecule and diverse transformations of the boration products.

Recommanded Product: Pyrazine-2-carboxylic acid. Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Product Details of 98-97-5. In 2021 TETRAHEDRON LETT published article about C-H BOND; PALLADIUM-CATALYZED TRIFLUOROMETHYLATION; FLUORINATION; ALKENES; FUNCTIONALIZATION; ARYL; ACTIVATION; EFFICIENT; AMINOTRIFLUOROMETHYLATION; PERFLUOROALKYLATION in [Wang, Kai; Zhang, Changjun; Xie, Yuanyuan] Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Peoples R China; [Hou, Jiahao; Wei, Tingting; Bai, Renren; Xie, Yuanyuan] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China in 2021, Cited 74. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

An eco-friendly and effective electrochemical process was developed for the ortho-trifluoromethylation of arylamines using CF3SO2Na as the trifluoromethyl source, affording the desired products in moderate to good yields with high regioselectivity under mild reaction conditions. Importantly, the requirement for both transition metals and oxidants utilized in previous methods were avoided. A radical mechanism was proposed on the basis of various control experiments. (C) 2020 Elsevier Ltd. All rights reserved.

Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.. Product Details of 98-97-5

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In 2020 BIOORG MED CHEM LETT published article about CYTOCHROME BC(1) COMPLEX; IRON-SULFUR PROTEIN; BC1 COMPLEX; DISCOVERY; SITE; FUNGICIDE; AMETOCTRADIN; RESISTANCE; MECHANISM; BINDING in [Cheng, Hua; Yang, Lu; Liu, Hong-Fu; Zhang, Rui] Hubei Univ Arts & Sci, Dept Chem Engn & Food Sci, Xiangyang 441053, Peoples R China; [Chen, Cheng] Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China; [Wu, Yuan; Jiang, Wen] Cent China Normal Univ, Coll Chem, Key Lab Pesticide & Chem Biol, Minist Educ, Wuhan 430079, Peoples R China in 2020, Cited 47. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. Name: Pyrazine-2-carboxylic acid

Mitochondrial complex III is one of the most promising targets for a number of pharmaceuticals and fungicides. Due to the wide-spread use of complex III-inhibiting fungicides, a considerable increase of resistance has occurred worldwide. Therefore, inhibitors with novel scaffolds and potent activity against complex III are still in great demand. In this article, a new series of amide compounds bearing the diaryl ether scaffold were designed and prepared, followed by the biological evaluation. Gratifyingly, several compounds demonstrated potent activity against succinate-cytochrome c reductase (SCR, a mixture of mitochondrial complex II and complex III), with compound 3w possessing the best inhibitory activity (IC50 = 0.91 +/- 0.09 mu mol/L). Additional studies verified that 3w was a new inhibitor of complex III. Moreover, computational simulations elucidated that 3w should bind to the Q(o) site of complex III. We believe this work will be valuable for the preparation and discovery of more complex III inhibitors.

Name: Pyrazine-2-carboxylic acid. Welcome to talk about 98-97-5, If you have any questions, you can contact Cheng, H; Yang, L; Liu, HF; Zhang, R; Chen, C; Wu, Y; Jiang, W or send Email.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

In 2019 J HETEROCYCLIC CHEM published article about ONE-POT SYNTHESIS; 2-SUBSTITUTED BENZOTHIAZOLES; OXIDATIVE CYCLIZATION; CATALYST; EFFICIENT; 2-ARYLBENZOXAZOLES; BASES in [Kashid, Bharat B.; Ghanwat, Anil A.; Dongare, Balasaheb B.] Solapur Univ, Sch Chem Sci, Chem Res Lab, Solapur 413255, MS, India; [Khedkar, Vijay M.] Shri Vile Parle Kelavani Mandals Inst Pharm, Dept Pharmaceut Chem, Dhule 424001, MS, India; [Shaikh, Mubarak H.; Deshpande, Prathmesh P.; Wakchaure, Yogesh B.] Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem, Aurangabad 431004, MS, India in 2019, Cited 52. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5. Quality Control of Pyrazine-2-carboxylic acid

A series of novel 2-substituted benzimidazole and benzoxazole derivatives as a potential antimicrobial and antioxidant agent were synthesized via coupling of N-methyl-o-phenylenediamine or 2-amino-phenol with aromatic aldehyde and acid in the presence of polyphosphoric acid as an efficient catalyst as well as solvent by conventional method in short reaction times with excellent yield. The newly synthesized benzimidazole and benzoxazole derivatives were evaluated for antimicrobial and antioxidant activity and exhibited excellent to good activities compared to the standard drugs. Furthermore, the theoretical predictions based on molecular docking against microbial DNA gyrase could provide an insight into the plausible mechanism of action and establish a link between the observed antimicrobial activity and the binding affinity shedding light on specific thermodynamic (bonded and nonbonded) interactions governing the activity. Furthermore, the synthesized compounds were analyzed for absorption, distribution, metabolism, and excretion properties and exhibited potential properties to build up as good oral drug candidates.

Welcome to talk about 98-97-5, If you have any questions, you can contact Kashid, BB; Ghanwat, AA; Khedkar, VM; Dongare, BB; Shaikh, MH; Deshpande, PP; Wakchaure, YB or send Email.. Quality Control of Pyrazine-2-carboxylic acid

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

HPLC of Formula: C5H4N2O2. Authors Guin, S; Dolui, P; Zhang, XL; Paul, S; Singh, VK; Pradhan, S; Chandrashekar, HB; Anjana, SS; Paton, RS; Maiti, D in WILEY-V C H VERLAG GMBH published article about in [Guin, Srimanta; Dolui, Pravas; Paul, Satyadip; Singh, Vikas Kumar; Pradhan, Sukumar; Chandrashekar, Hediyala B.; Anjana, S. S.; Maiti, Debabrata] Indian Inst Technol, Dept Chem, Mumbai 400076, Maharashtra, India; [Zhang, Xinglong; Paton, Robert S.] Univ Oxford, Chem Res Lab, Dept Chem, Mansfield Rd, Oxford OX1 3TA, England in 2019, Cited 72. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5

Directed C-H functionalization has been realized as a complementary tool to the traditional approaches for a straightforward access of non-proteinogenic amino acids; albeit such a process is restricted mostly up to the gamma-position. In the present work, we demonstrate the diverse (hetero) arylation of amino acids and analogous aliphatic amines selectively at the remote delta-position by tuning the reactivity controlled by ligands. An organopalladium delta-C(sp(3))-H activated intermediate has been isolated and crystallographically characterized. Mechanistic investigations carried out experimentally in conjunction with computational studies shed light on the difference in the mechanistic picture depending on the substrate structure.

Welcome to talk about 98-97-5, If you have any questions, you can contact Guin, S; Dolui, P; Zhang, XL; Paul, S; Singh, VK; Pradhan, S; Chandrashekar, HB; Anjana, SS; Paton, RS; Maiti, D or send Email.. HPLC of Formula: C5H4N2O2

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

An article A structural and thermodynamic study of the complexes of U(vi) with azinecarboxylates WOS:000454920800018 published article about AQUEOUS-SOLUTION; EQUILIBRIUM-CONSTANTS; CARBOXYLIC-ACIDS; URANIUM(VI); CRYSTAL; ION; CHEMISTRY; LIGAND in [Lv, Lina; Chen, Baihua; Liu, Jun; Yang, Yanqiu] China Acad Engn Phys, Inst Nucl Phys & Chem, Mianyang 621900, Sichuan, Peoples R China; [Chen, Jing; Xu, Chao] Tsinghua Univ, Inst Nucl & New Energy Technol, Beijing 100084, Peoples R China in 2019, Cited 42. Category: Pyrazines. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5

Complexation of U(vi) with pyridazine-3-carboxylate (PDZ) and pyrazine-2-carboxylate (PAZ) was studied by spectrophotometry, potentiometry and microcalorimetry in 1.0 mol dm(-3) NaClO4. Three complexes, [UO2L](+), UO2L2(aq) and [UO2L3](-), were identified and their stability constants (log) and the corresponding formation enthalpies were determined. The thermodynamic parameters indicate that the formation of the three complexes is endothermic and driven exclusively by entropy. H-1 and C-13-NMR data provide insight into the coordination modes of the complexes which corroborate with the thermodynamic data. Ligands chelate to U(vi) via (2)(N,O) coordination mode in complexes [UO2L](+) and UO2L2(aq). The crystal structures of four U(vi) complexes, [(UO2)(PAZ)(2)(H2O)]H2O(i), [(UO2)(PDZ)(2)(H2O)](ii), [(UO2)(PDZ)(3)Na2ClO4]2H(2)O(iii), and [(UO2)(2)(PDZ)(4)(H2O)(2)]2H(2)O(iv), were determined by single-crystal X-ray diffraction and compared with the U(vi) complex with picolinate (PA) (CH6N3)[UO2(PA)(3)] in the literature. The structure data suggest that the carboxylates coordinate with uranium in O?C-O-U mode. The strengths of the U-O-C-C-N chelate cycles in the U(vi)/L complexes decrease with the trend of PA > PDZ > PAZ, which is in great agreement with the trend of thermodynamic parameters in aqueous solutions. It is interesting that in compound II two PDZ molecules coordinate with U(vi) in cis-planar positions via (2)(N,O) mode, but in other metal complexes of the three ligands having the same (2)(N,O) coordination mode the two ligand molecules are all in trans-arrangement. In the dimeric complex IV, one ligand coordinate with U(vi) in (2)(N,O) mode, while the other does it in (2)-L-(2)(O:O) mode respectively.

Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.. Category: Pyrazines

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Category: Pyrazines. Authors Packiaraj, S; Kousalya, L; Pushpaveni, A; Poornima, S; Puschmann, H; Govindarajan, S in SPRINGER published article about in [Packiaraj, S.] Sri Krishna Coll Engn & Technol, Sci & Humanities Chem, Coimbatore 641008, Tamil Nadu, India; [Packiaraj, S.; Pushpaveni, A.; Poornima, S.; Govindarajan, S.] Bharathiar Univ, Dept Chem, Coimbatore 641046, Tamil Nadu, India; [Kousalya, L.] Nirmala Coll Women, Dept Bot, Coimbatore 641018, Tamil Nadu, India; [Pushpaveni, A.] Kongunadu Arts & Sci Coll, Dept Chem, Coimbatore 641029, Tamil Nadu, India; [Puschmann, H.] Univ Durham, Dept Chem, South Rd, Durham DH1 3LE, England in 2021, Cited 43. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5

In general, molecules with certain functional groups such as amine (-NH2) and carboxyl (-COOH) can promote the growth of co-crystals leading to the formation of supramolecular networks. However, if the differences in the pKa values of the two molecules are large [pKa (base)-pKa (acid)], salts can result instead of ‘real’ co-crystals. Here, we report the formation of such salt by letting pyrazine-2-carboxylic acid (pKa = 2.9) crystallize together with aminoguanidine (pKa = 11.5; high Delta pka = 8.6) a nitrogen-rich organic base. The title salt has been prepared by slow evaporation of an equimolar ratio of guanylhydrazine bicarbonate (i.e., aminoguanidine bicarbonate (AgunH.HCO3)) and pyrazine-2-carboxylic acid (Pymca) in aqueous medium. The salt was characterized by IR spectroscopy, powder and single-crystal X-ray diffraction techniques. This material shows enhanced antioxidant activity and this is due to the crucial role of hydrazinic moiety in the aminoguanidinium salt.

Welcome to talk about 98-97-5, If you have any questions, you can contact Packiaraj, S; Kousalya, L; Pushpaveni, A; Poornima, S; Puschmann, H; Govindarajan, S or send Email.. Category: Pyrazines

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Safety of Pyrazine-2-carboxylic acid. In 2019 MOLECULES published article about STANDARD MOLAR ENTHALPY; STRUCTURE-PROPERTY RELATIONSHIPS; THERMODYNAMIC PROPERTIES; IONIC LIQUIDS; THERMOPHYSICAL PROPERTIES; TEMPERATURE-RANGE; GROUP ADDITIVITY; VAPOR-PRESSURES; THERMAL-ANALYSIS; COMPUTATIONAL THERMOCHEMISTRY in [Naef, Rudolf] Univ Basel, Dept Chem, CH-4003 Basel, Switzerland in 2019, Cited 287. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

A universally applicable method for the prediction of the isobaric heat capacities of the liquid and solid phase of molecules at 298.15 K is presented, derived from their true volume. The molecules’ true volume in A(3) is calculated on the basis of their geometry-optimized structure and the Van-der-Waals radii of their constituting atoms by means of a fast numerical algorithm. Good linear correlations of the true volume of a large number of compounds encompassing all classes and sizes with their experimental liquid and solid heat capacities over a large range have been found, although noticeably distorted by intermolecular hydrogen-bond effects. To account for these effects, the total amount of 1303 compounds with known experimental liquid heat capacities has been subdivided into three subsets consisting of 1102 hydroxy-group-free compounds, 164 monoalcohols/monoacids, and 36 polyalcohols/polyacids. The standard deviations for Cp(liq,298) were 20.7 J/mol/K for the OH-free compunds, 22.91 J/mol/K for the monoalcohols/monoacids and 16.03 J/mol/K for the polyols/polyacids. Analogously, 797 compounds with known solid heat capacities have been separated into a subset of 555 OH-free compounds, 123 monoalcohols/monoacids and 119 polyols/polyacids. The standard deviations for Cp(sol,298) were calculated to 23.14 J/mol/K for the first, 21.62 J/mol/K for the second, and 19.75 J/mol/K for the last subset. A discussion of structural and intermolecular effects influencing the heat capacities as well as of some special classes, in particular hydrocarbons, ionic liquids, siloxanes and metallocenes, has been given. In addition, the present method has successfully been extended to enable the prediction of the temperature dependence of the solid and liquid heat capacities in the range between 250 and 350 K.

Safety of Pyrazine-2-carboxylic acid. Welcome to talk about 98-97-5, If you have any questions, you can contact Naef, R or send Email.

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

COA of Formula: C5H4N2O2. van der Westhuyzen, CW; Haynes, RK; Panayides, JL; Wiid, I; Parkinson, CJ in [van der Westhuyzen, Christiaan W.; Panayides, Jenny-Lee] CSIR Biosci, ZA-0001 Pretoria, South Africa; [Haynes, Richard K.] North West Univ, Ctr Excellence Pharmaceut Sci, ZA-2531 Potchefstroom, South Africa; [Wiid, Ian] Stellenbosch Univ, SAMRC Ctr TB Res, DST NRF Ctr Excellence Biomed TB Res, Tygerberg, South Africa; [Parkinson, Christopher J.] Charles Sturt Univ, Sch Biomed Sci, Orange, NSW 2800, Australia published Anti-Mycobacterial Peroxides: A New Class of Agents for Development Against Tuberculosis in 2020, Cited 36. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5.

Background: With few exceptions, existing tuberculosis drugs were developed many years ago and resistance profiles have emerged. This has created a need for new drugs with discrete modes of action. There is evidence that tuberculosis (like other bacteria) is susceptible to oxidative pressure and this has yet to be properly utilised as a therapeutic approach in a manner similar to that which has proven highly successful in malaria therapy. Objective: To develop an alternative approach to the incorporation of bacterial siderophores that results in the creation of antitubercular peroxidic leads for subsequent development as novel agents against tuberculosis. Methods: Eight novel peroxides were prepared and the antitubercular activity (H(37)Rv) was compared to existing artemisinin derivatives in vitro. The potential for toxicity was evaluated against the L6 rat skeletal myoblast and HeLa cervical cancer lines in vitro. Results: The addition of a pyrimidinyl residue to an artemisinin or, preferably, a tetraoxane peroxidic structure results in antitubercular activity in vitro. The same effect is not observed in the absence of the pyrimidine or with other heteroaromatic substituents. Conclusion: The incorporation of a pyrimidinyl residue adjacent to the peroxidic function in an organic peroxide results in anti-tubercular activity in an otherwise inactive peroxidic compound. This will be a useful approach for creating oxidative drugs to target tuberculosis.

Bye, fridends, I hope you can learn more about C5H4N2O2, If you have any questions, you can browse other blog as well. See you lster.. COA of Formula: C5H4N2O2

Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem