Recommanded Product: Pyrazine-2-carboxylic acid. Recently I am researching about PHARMACEUTICAL COCRYSTALS; SALTS; DESIGN; POLYMORPHISM; INVESTIGATE; SOLUBILITY; STABILITY; BEHAVIOR; COFORMER; LIQUID, Saw an article supported by the FAPESP foundation (Brazil)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2013/09022-7, 2017/14936-9, 2018/12463-9, 2018/24378-6]; CNPq foundation (Brazil)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ) [141829/2017-6]; CAPES foundation (Brazil)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]; CPID/CDMF foundation (Brazil). Published in SPRINGER in DORDRECHT ,Authors: de Almeida, AC; Ferreira, PO; Torquetti, C; Ekawa, B; Carvalho, ACS; dos Santos, EC; Caires, F. The CAS is 98-97-5. Through research, I have a further understanding and discovery of Pyrazine-2-carboxylic acid
Novel cocrystals of ciprofloxacin with pyrazinoic acid and p-aminobenzoic acid in the 1:1 stoichiometric ratio were obtained by the mechanochemical method, under conditions of liquid-assisted grinding (LAG/ethanol) and neat grinding. They were characterized by powder X-ray diffractometry, infrared spectroscopy, simultaneous thermogravimetry, differential thermal analysis, differential scanning calorimetry (DSC) and DSC-Microscopy system. The results confirmed the successful synthesis of the cocrystals and indicated the functional groups responsible for the formation of the new supramolecular synthons. In addition, from the thermal analysis, it was possible to evaluate the thermal stability, composition, crystallization processes during heating, polymorphic transitions and construct the binary phase diagrams.
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Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem