An article Efficient synthesis of novel RGD based peptides and the conjugation of the pyrazine moiety to their N-terminus WOS:000459942300029 published article about ADHESION MOLECULE L1; CELL-ADHESION; INTEGRIN ALPHA(V)BETA(3); CYCLIC RGD; VITRONECTIN-RECEPTOR; MALIGNANT-MELANOMA; DISCOVERY; STRATEGIES; BINDING; DESIGN in [Hamdan, Fatima; Bigdeli, Zahra; Balalaie, Saeed] KN Toosi Univ Technol, Peptide Chem Res Ctr, POB 15875-4416, Tehran, Iran; [Balalaie, Saeed] Kermanshah Univ Med Sci, Med Biol Res Ctr, Kermanshah, Iran; [Sewald, Norbert; Michalek, Carmela] Bielefeld Univ, Dept Chem, Organ & Bioorgan Chem, Univ Str 25, D-33615 Bielefeld, Germany in 2019, Cited 97. Recommanded Product: 98-97-5. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5
The synthesis of modified RGD peptides and their conjugation to the pyrazine skeleton at their N-terminus are described. To modify and alter the RGD sequence, short bioactive peptides such as FALKF and NGRG were added to the RGD N-terminus. Moreover, the in vitro investigation of these modified peptides, by a cell adhesion assay using the melanoma cell lines M21 expressing alpha(v)beta(3) and M21L lacking alpha(v) expression, was made and interestingly peptide 4 containing the pyrazine moiety with the linear RGDFAKLF sequence gave the best IC50 value with M21 and all the peptides were unable to bind to M21L, demonstrating the selective recognition to alpha(v)beta(3). The results showed pyrazine plays an essential role in the activity of the peptides. From these results, we can suggest that these peptides can affect cancer cells by abrogation of cell adhesion (cell migration).
About Pyrazine-2-carboxylic acid, If you have any questions, you can contact Hamdan, F; Bigdeli, Z; Balalaie, S; Sewald, N; Michalek, C or concate me.. Recommanded Product: 98-97-5
Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
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