14508-49-7, name is 2-Chloropyrazine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 14508-49-7
A mixture of CHLOROPYRAZINE (9.6 g, 83.3 MMOL) and hydrogen peroxide solution (30%, 16 mi) in glacial acetic acid (26 ml) was heated at 70 C for 18 hours. The mixture was allowed to cool to room temperature, poured into water (250 ml) and extracted with DICHLOROMETHANE (3 x 100 ML). The DICHLOROMETHANE extracts were combined, washed with saturated sodium bicarbonate solution (2 x 70 ML), water (3 x 100 ML) and brine (100 ml). The organic portion was dried under sodium sulfate and evaporated in vacuo to give a white solid which was recrystallised from absolute ethanol to give the title compound (0.45 g). ‘H NMR (CDCI3) 8.27-8. 26 (1H, d), 8.15 (1 H, S), 8.03-8. 02 (1 H, dd).
The synthetic route of 14508-49-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; WO2004/56369; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem