Reference of 486424-37-7,Some common heterocyclic compound, 486424-37-7, name is 3-Amino-6-bromopyrazine-2-carboxylic acid, molecular formula is C5H4BrN3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
CDI (2.23 g, 13.8 mmol) was added to a suspension of commercial 3-amino-6- bromopyrazine-2-carboxylic acid (2.00 g, 9.17 mmol) in DMF (20 ml). The reaction was stirred at RT for 16 h. The reaction mixture was cooled (0 C) then diluted with water (20 ml). The solid was collected by filtration then washed with the minimum volume of water and cooled (0 C) MeCN then dried under vacuum to afford the product as a yellow solid (2.23 g, 86%). 1H NMR (250 MHz, DMSO-cfe) delta 8.55 (s, 2H), 7.96 – 7.82 (m, 3H), 7.15 – 7.07 (dm, 1 H). LC/MS (System A, MeOH quench): m/z (ESI+) = 232 [Methyl ester M(79Br)H+], 234 [Methyl ester M(81Br)H+]), Rt = 0.87 min, UV purity = 95%.
The synthetic route of 486424-37-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ENTERPRISE THERAPEUTICS LIMITED; MCCARTHY, Clive; HARGRAVE, Jonathan David; HAY, Duncan Alexander; SCHOFIELD, Thomas Beauregard; WENT, Naomi; (111 pag.)WO2017/221008; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem