In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 486424-37-7, name is 3-Amino-6-bromopyrazine-2-carboxylic acid belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. category: Pyrazines
Block B can be prepared according to scheme 2 in FIG. 2. Referring to FIG. 2, the synthesis of Block B can be performed as described below. (0164) Intermediate 6 Block B [0029] To a solution of Intermediate 6 (6.0 g, 27.4 mmol) in DMSO (30 mL) was added CDI (8.9 g, 54.8 mmol), DIPEA (3.8 g, 30.1 mmol) and DMAP (0.17 g, 1.37 mmol). The solution was stirred at rt for 4 hours. Aniline (2.5 g, 27.4 mmol) was added and the mixture was stirred at rt overnight. Water was added and the formed solid was collected by filtration. The crude product was purified by silica-gel column to afford 2.5 g of Block B (31 %) as yellow solid. (0165) [0030] LC-MS (M+l): 293.2; 1H MR (400 MHz, DMSO-d6) 510.28 (s, 1H), 8.42 (s, 1H), 7.78 (d, J = 8.0 Hz, 2H), 7.74 (s, 2H), 7.36 (t, J = 8.0 Hz, 2H), 7.13 (t, J = 7.6 Hz, 1H) .
The synthetic route of 486424-37-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERRIMACK PHARMACEUTICALS, INC.; DRUMMOND, Dary| C.; GENG, Bolin; KIRPOTIN, Dmitri B.; TIPPARAJU, Suresh, K.; KOSHKARYEV, Alexander; ALKAN, Ozan; (142 pag.)WO2017/123588; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem