In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1458-16-8 as follows. 1458-16-8
To a mixture under argon of 0.5 mmol of intermediate -if-,0.025 mmol of Cul and 1 mmol of potassium carbonate in a small thick glass reactor (Ace Tube) , are successively added 1 mL of isopropanol, 1 mmol of ethylene glycol and 0.75 mmol of thiophenol. The reactor is sealed with a Teflon stopper, placedunder magnetic stirring and heated two hours at 80C. The reaction mixture is cooled to room temperature and the thus obtained precipitate isolated through filtration, washed and recrystallized from hot methanol (yield : 88%)LCMS (IE, m/z): (M+1) 248; ?H NMR: oH ppm 400 MHz, DMSO: 7.19 -7.14 (3H, m, CHarom.) , 7.30-7.26 (2H, m, CHarom.) , 7.97 (1H, 5,CHarom)
According to the analysis of related databases, 1458-16-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PIERRE FABRE MEDICAMENT; KALOUN, El Bachir; BEDJEGUELAL, Karim; MORDANT, Celine; RABOT, Remi; TAMBURLIN, Isabelle; FOURNIER, Emmanuel; SCHMITT, Philippe; (74 pag.)WO2016/207345; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem