33332-28-4, name is 2-Amino-6-chloropyrazine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 2-Amino-6-chloropyrazine
Example 1C 6-(3-butenyloxy)-2-pyrazinamine A suspension of NaH (60percent, 618 mg, 15.45 mmol) in dioxane (30 mL) at 0° C. was treated with 3-buten-1-ol (1.33 mL, 15.45 mmol), stirred for 2 hours, treated with 2-amino-6-chloropyrazine (1 g, 7.72 mmol), stirred at 100° C. for 2.5 days, cooled to room temperature, and diluted with ethyl acetate. The mixture was washed with water, dried (MgSO4), filtered, and concentrated. The concentrate was purified by flash column chromatography eluding with hexanes/ethyl acetate (2:1) to provide the desired product (390 mg, 31percent). MS (DCI/NH3) m/z 166.12 (M+H)+; 1H NMR (500 MHz, benzene-d6) delta 2.66 (m, 2H), 4.42 (t, J=6.87 Hz, 2H), 5.24 (dd, J=10.22, 1.98 Hz, 1H), 5.30 (m, 1H), 6.04 (m, 1H), 7.64 (s, 1H), 7.65 (s, 1H).
The synthetic route of 33332-28-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Lin, Nan-Horng; Li, Gaoquan; Przytulinska, Magdalenna K.; Sowin, Thomas J.; Sullivan, Gerard M.; Tao, Zhi-Fu; Tong, Yunsong; Wang, Le; US2005/215556; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem