Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 95-89-6, name is 3-Chloro-2,5-dimethylpyrazine, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C6H7ClN2
Intermediate 18: 3,6-d imethyllyrazin-2-amineAmmonia in water (3 mL, 48.5 mmol) was added to 3-chloro-2,5-dimethylpyrazine (0.121 mL, 1 mmol) and the mixture heated by microwaves to 165 C for 7 hours. Following LCMS analysis, the reaction was then reheated to 165 C for a further 16 hours, by microwaves. After cooling, thesolvent was removed under a stream of nitrogen and the crude redissolved in dichloromethane (20mL). Water (25 mL) was added and the mixture basified to pHl4 using sodium hydroxide solution(18 N). The organic layer was removed and the aqueous layer extracted with dichloromethane (5 x25 mL). The organic phases were combined and dried using a hydrophobic frit, then evaporated invacuoto give the title product (109 mg). This was used directly in the next step with no furtherpurification. LCMS (2 mm, high pH) Rt 0.47 mi m/z (ESj 124 (M+H).1H NMR (400 MHz, CHLOROFORM-o) O ppm 7.73 (5, 1 H), 4.42 (br. s., 2 H), 2.37 (5, 3 H), 2.35 (5, 3H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 95-89-6.
Reference:
Patent; GLAXO GROUP LIMITED; BIRAULT, Veronique; CAMPBELL, Amanda, Jennifer; HARRISON, Stephen; LE, Joelle; SHUKLA, Lena; WO2013/160419; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem