Adding a certain compound to certain chemical reactions, such as: 143591-61-1, name is 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 143591-61-1, Recommanded Product: 3-Bromo-8-chloroimidazo[1,2-a]pyrazine
A mixture of compound 102 (2.00 g, 8.6 mmol), conc. aqueous NH4OH (60 mL) and 2-propanol (6 mL) was stirred in a closed pressure vessel at 85 C. for 3 days. The reaction mixture was cooled to 25 C., diluted with water (120 mL) and stirred at 25 C. for 10 minutes. The resulting heterogeneous solution was filtered, the solid was washed with water (3×) and air dried overnight. This gave compound 108 as a beige solid 1.50 g (82%). 1H-NMR (400 MHz, DMSO-d6) delta 7.66 (s, 1H), 7.56 (d, 1H), 7.35 (d, 1H), 7.1 (bs, 2H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Schering Corporation; US2007/105864; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem