Reference of 622392-04-5, A common heterocyclic compound, 622392-04-5, name is 2-Bromo-5-iodopyrazine, molecular formula is C4H2BrIN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 25 Step 1. 2-iodo-5-methoxy-pyrazine. Sodium methoxide (25% wt. in MeOH,0.321 mL, 1.4 mmol) was combined with N-methyi pyrrolidine (NMP) (1.28 mL) and warmed to 60 C. 2-bromo-5-iodo-pyrazine (0.40 g, 1.4 mmol) was added. The suspension was stirred at 60 0C for 1 hour. Combined with an additional 100 mg previously run reaction prior to work-up. Reaction mixture was partitioned between H2O and ethyl acetate and the aqueous layer was extracted (3x) with ethyl acetate. The combined extracts were dried over MgSO4, filtered and concentrated to give a brown oil which solidified to obtain 406 mgs of crude material. 1H NMR (400 MHz, CHLOROFORM-d) d ppm 3.90 (s, 3 H), 8.03 (d, J=1.4 Hz, 1 H), 8.29 (d, J=1.4 Hz, 1 H); MS (APCI+, m/z) 237.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; PFIZER PRODUCTS INC.; WO2007/72151; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem