Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 221136-66-9, name is Ethyl 2-(3-bromo-6-methyl-2-oxopyrazin-1(2H)-yl)acetate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: Ethyl 2-(3-bromo-6-methyl-2-oxopyrazin-1(2H)-yl)acetate
EXAMPLE 5 r3-(2.2-Difluoro-2-phenyl-ethylamino)-6-methyl-2-oxo-2H-pyrazin-1-vn- acetic acidThe title compound was prepared according to the procedure shown below and described in details thereinafter.n-Butanol (2919.6 g, 3.6 I), 3-bromo-6-methyl-2-oxo-2(2H-pyrazine acetic acid) ethyl ester (Reagent (A) 600 g, 2.14 mol 1 equiv.)), and 2,2- difluoro-2-phenylethylamine (Reagent (B) 675 g, 4.29 mol, 2.00 equiv.) were charged to the reaction vessel and the reaction mixture heated to reflux. The reaction mixture was maintained at reflux. The reaction was then cooled to 750C and a 25% solution of sodium hydroxide (759 g, 600 ml 2.68 equiv.) was added. The reaction mixture was stirred at 750C. A 22% hydrochloric acid solution (1010 g, 900 ml, 3.13 equiv.) was then added slowly to the reaction mixture. The reaction mixture was allowed to cool to room temperature and then stirred overnight. The next morning the reaction mixture was cooled to 1 O0C, filtered, the filtrate washed with n-butanol (2.1 I), and then dried at 550C to yield the title compound as a residue.
According to the analysis of related databases, 221136-66-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2007/146553; (2007); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem