Adding a certain compound to certain chemical reactions, such as: 4774-14-5, name is 2,6-Dichloropyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4774-14-5, Formula: C4H2Cl2N2
2,6-dichloropyrazine dissolved in 200 mL dry toluene in an oven dried flask, were added under stirring: 0.42 g (0.46 mmol) Pd(0)2 dba3, 0.83 g (1.34 mmol) 2,2′-bis(diphenylphosphino)-1,1′-binaphtyl (BINAP), 7.36 g (40.2 mmol) 3,4,5-trimethoxyanilin and 4.41 g (46.9 mmol) Na-tert-butoxide. The reaction mixture was heated at 90 C. (bath temperature) for 4 hours under N2. After cooling, the toluene solution was filtered. The solid was retaken in 100 mL Me2CO, filtered through a 5 cm column of Kieselgel 60, and the resulting solution evaporated under vacuum. A portion of 2.53 g of title compound was obtained. The toluene filtrate was evaporated to dryness and then retaken in 70-80 mL boiling AcOEt. The solution was kept in a refrigerator over night and 2.57 g of solid title compoundcompound were collected by filtration. The filtrate was reduced to 18-20 mL and submitted to HPLC (Kieselgel 60, 0.015-0.043; eluent: AcOEt:cycloxane 2:1). A third fraction of 0.94 g of title compoundcompound was collected. The total yield was 6.04 g (61.1%). 1H-NMR (DMSO), delta (ppm), J (Hz): 3.63 (s, 3H, CH3O(4′)), 3.77 (s, 6H, CH3O(3’+5′)), 7.02 (s, 2H, Harom(2’+6′)), 7.96 (s, 1H, HP5), 8.14 (s, 1H, HP3), 9.79 (s, 1H, NH); MS, (C13H14ClN3O3), m/z: 296 [M++1, 100].
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,6-Dichloropyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE WELLCOME TRUST LIMITED; US2008/15191; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem