Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 55557-52-3, name is 3-Chloropyrazine-2-carbonitrile, A new synthetic method of this compound is introduced below., SDS of cas: 55557-52-3
An aqueous K2CO3 solution (2.0 M, 30 mL) is added to a solution of 3-chloro- pyrazine-2-carbonitrile (21.5 mmol) and the respective phenylboronic acid (21.5 mmol) in DME (65 mL). Triphenylphosphine (3.21 mmol) and palladium(II) acetate (1.06 mmol) are added and the mixture is stirred at 900C for 16 h and allowed to reach RT. EtOAc is added and the mixture is filtered through Celite, dried over MgSO4 and concentrated in vacuo to give the respective carbonitrile derivative which is diluted with MeOH (100 mL) and aqueous NaOH solution (4.0 M, 160 rnL). The mixture is stirred at 85C for 16 h, cooled to RT and concentrated partially in vacuo to remove methanol. Water and cone, hydrochloric acid are added (pH ~ 2) and the obtained precipitate is filtered off. The residue is dissolved in a mixture of EtOAc and DCM, dried over MgSO4 and concentrated in vacuo to give the desired acid derivative.3-(3-Methoxy-phenyl)-pyrazine-2-carboxylic acid prepared by reaction of S-chloro-pyrazine-l-carbonitrile with 3-methoxybenzene- boronic acid. LC-MS (A): tR = 0.71 min; [M+H]+ = 231.5.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ACTELION PHARMACEUTICALS LTD; AISSAOUI, Hamed; BOSS, Christoph; BROTSCHI, Christine; KOBERSTEIN, Ralf; SIEGRIST, Romain; SIFFERLEN, Thierry; TRACHSEL, Daniel; WILLIAMS, Jodi T.; WO2010/44054; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem