In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 19745-07-4 as follows. Recommanded Product: 19745-07-4
To a mixture of 2,5-dichloropyrazine in 2-propanol (0.2 M) was added 4- hydroxypiperidine (2.2 equiv.). The reaction was heated in the microwave at 160 0C for 10 min.The solvent was evaporated under reduced pressure and the title compound was purified by flash chromatography eluting with ethyl acetate
According to the analysis of related databases, 19745-07-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK FROSST CANADA LTD.; WO2008/46226; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem