Adding a certain compound to certain chemical reactions, such as: 1458-01-1, name is Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1458-01-1, name: Methyl 3,5-diamino-6-chloropyrazine-2-carboxylate
Example 310; Synthesis of 3,5-diamino-6-chloropyrazine-2-carboxylic acid[0247] To a solution of methyl 3,5-diamino-6-chloropyrazine-2-carbamate (5 g, 0.025 mols ) in 2:1 THF/MeOH (90 mL) was added IM LiOH (62 mL, 0.062 mols ). After the reaction was stirred at r.t. 72 hrs, IN HCl (62 mL, 0.062 mols ) was added. The reaction was filtered and washed with water (3 x 10 mL) to give 3,5-diamino-6- chloropyrazine-2-carboxylic acid as white solid 4.3 g (93 percent yield). LCMS (m/z): 189.1 (MH+); LC Rt = 1.05 min.
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Reference:
Patent; NOVARTIS VACCINES AND DIAGNOSTICS, INC.; WO2008/106692; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem