Reference of 74290-65-6, A common heterocyclic compound, 74290-65-6, name is 3-Bromo-5-methylpyrazin-2-amine, molecular formula is C5H6BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3-Bromo-5-methylpyrazin-2-amine (7.64 g, 40.6 mmol), triethylamine (12.3 g, 122mmol), cuprous iodide (0.77 g, 4.06 mmol) and palladium(II)bis(triphenylphosphine) dichloride(2.85 g, 4.06 mmol) were dissolved in tetrahydrofuran (150 mL). The mixture was stirred at rt,then trimethylsilylacetylene (8.00 mL, 56.9 mmol) was added dropwise slowly to the mixture.The resulting mixture was continued to stir for 4 h.The reaction mixture was diluted with ethylacetate (50 mL). The mixture was filtered. The filtrate was concentrated in vacuo, and theresidue was purified by silica gel column chromatography (PE/EtOAc (v/v) = 3011) to give thetitle compound as a light yellow solid (7 .0 g, 84 % ).MS (ESI, pos. ion) m/z: 206.1 [M+Ht.
The synthetic route of 74290-65-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; TANG, Changhua; REN, Qingyun; YIN, Junjun; YI, Kai; LEI, Yibo; WANG, Yejun; ZHANG, Yingjun; (303 pag.)WO2018/108125; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem