Synthetic Route of 4745-93-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4745-93-1 as follows.
1.1 A solution of 2.57 g (11.0 mmol) of iodine in 15 ml of DMF is added dropwise to a mixture of 1.25 g (10.0 mmol) of 5H-pyrrolo[2,3-b]pyrazine and 1.65 g (25.0 mmol) of solid potassium hydroxide in 15 ml of DMF, and the mixture is subsequently stirred at room temperature for 45 minutes. The reaction mixture is poured into 200 ml of ice-water (containing 0.5% by weight of ammonia and 0.1% by weight of sodium disulfite) and left at 5 C. for 12 hours. The resultant precipitate is filtered off with suction, washed with 100 ml of ice-water and dried in vacuo: 7-iodo-5H-pyrrolo[2,3-b]pyrazine as yellow solid.
According to the analysis of related databases, 4745-93-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK PATENT GMBH; Dorsch, Dieter; Wucherer-Plietker, Margarita; Mueller, Thomas J.J.; Merkul, Eugen; US2013/217951; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem