Share a compound :

Reference of 5521-55-1, A common heterocyclic compound, 5521-55-1, name is 5-Methylpyrazine-2-carboxylic acid, molecular formula is C6H6N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5-Methyl-pyrazine-2-carboxylic acid (691 mg, 5 mmol) was stirred in toluene (15 mL) and treated with TEA (765 mL, 5.5 mmol) followed by diphenylphosphoryl azide (1.0 mL, 5.0 mmol). The resulting solution was stirred for 30 min, then used directly.A solution of 5-methyl-pyrazine-2-carbonyl azide (1.0 mmol) in toluene was heated at 900C for 10 min. The reaction flask was removed from the heating bath and the brown solution was treated with 2- (1,4- dimethyl-piperazin-2-ylmethoxy) -5-methyl-phenylamine EPO (0.25 g, 1.0 iranol) . The flask was returned to the heating bath and heated at 40C for 4 h. The mixture was allowed to cool, then filtered to give the product as a tan powder. 1H-NMR (400 MHz, CDCl3) delta 10.90 (s, 1, H), 8.4 (s, 1, H), 8.2 (m, 3, H), 6.8 (m, 2, H), 4.2 (dd, 1, H), 3.9 (t, 1, H),.3.1 (d, 1, H), 2.8 (br d, 1, H), 2.6 (m, 2, H), 2.5 (s, 3, H), 2.4 (m, 1, H), 2.4 (s, 3, H), 2.3 (S, 3, H), 2.25 (m, 1, H), 2.2 (s, 3, H), 2.1 (m, 1, H). LRMS (esi, positive) m/e 385.30 (M+l) .

The synthetic route of 5521-55-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ICOS CORPORATION; WO2006/105262; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem