Electric Literature of 36070-80-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 36070-80-1 as follows.
[00778] To a solution of lenalidomide (0.2g, 0.77 mmol) in DMF (4 mL) was added 5-chloropyrazine-2-carboxylic acid (0.15g, 0.95 mmol), HATU, (0.29g, 0.77 mmol), and DIPEA (0.27mL, 1.54 mmol). The reaction was stirred at room temperature for 1 hr before it was quenched with saturated NH4C1 (5 mL). The mixture was extracted with EtOAc (10 mLx3), and the combined organic phase was dried over Na2SO4 and concentrated. Column chromatography gave 5-chloro-N-(2- (2,6-dioxopiperidin-3-yl)- 1 -oxoisoindolin-4-yl)pyrazine-2-carboxamide (0.1 g, 33%).
According to the analysis of related databases, 36070-80-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SYNTA PHARMACEUTICALS CORP.; CHIMMANAMADA, Dinesh, U.; YING, Weiwen; WO2013/158644; (2013); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem