Electric Literature of 63286-28-2,Some common heterocyclic compound, 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, molecular formula is C4H5ClN4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
-Chloro-3-hydrazinylpyrazine (440 g, 3.0 mol) was suspended in acetic acid (500 mL) and cooled to lOoC. A solution of sodium nitrite (220 g, 3.2 mol) in water (200 mL) at 10 C was added. The resulting mixture was stirred at 10 C for 1 h, during which time a crystalline solid precipitated. The precipitate was collected by filtration, washed with ethanol (200 mL) and dried to afford the desired product as a red solid (350 g, 73% yield).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloro-3-hydrazinylpyrazine, its application will become more common.
Reference:
Patent; KALYPSYS, INC.; CHEN, Pingyun; CARINO, Stephen, A., R.; COUCH, Ricky, W.; KINDER, Daniel, S.; NORTON, Beth, A.; WO2013/39785; (2013); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem