Adding a certain compound to certain chemical reactions, such as: 4858-85-9, name is 2,3-Dichloropyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4858-85-9, Recommanded Product: 4858-85-9
A. Preparation of the intermediate compoundsA1. Preparation of intermediate compound 3 a) Preparation of intermediate compound 12,3-Dichloropyrazine (10 g, 62.12 mmol) and 1-(phenylmethyl)-4-piperidin- amine (13.73 ml_, 67.12 mmol) were dissolved in DMF (60 ml). Then Na2CO3 (10.09 g, 114.10 mmoi) was added. The reaction was stirred at 130 0C for 16 hours. The solid was filtered off, washed with AcOEt and the solvent was evaporated till dryness. The product was dissolved in AcOEt, washed with H2O and brine, dried with MgSO4 and evaporated under vacuum. The product was used without any further purification yielding 15 g of the desired intermediate compound 1 (74 %).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,3-Dichloropyrazine, and friends who are interested can also refer to it.
Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2007/71639; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem