Reference of 14667-55-1, A common heterocyclic compound, 14667-55-1, name is 2,3,5-Trimethylpyrazine, molecular formula is C7H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE IV Preparation Of 1-(2,3,5-Trimethyl-6-pyrazinyl)-1-propanone STR8 The reaction of trimethylpyrazine and freshly distilled propionaldehyde is carried out as described in Example I on the same molar scale. Preparative thick layer chromatography (2000mu silica gel GF, developed in 5% acetone/hexane) of the crude reaction product gives a 48% yield of 1-(2,3,5-trimethyl-6-pyrazinyl)-1-propanone (mp 65-67 C.). An analytically pure sample for odor and flavor evaluation is obtained by preparative GLC (1/4″*15′ Carbowax 20M-TPA). The structure is verified by spectroscopy. Anal. calc. for C10 H14 N2 O: C, 67.39; H, 7.92; N, 15.72; Found: C, 67.24; H, 8.13; N, 15.62.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Philip Morris Incorporated; US4588813; (1986); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem