Application of 33332-25-1, A common heterocyclic compound, 33332-25-1, name is Methyl 5-chloropyrazine-2-carboxylate, molecular formula is C6H5ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
863 mg of 5-chloropyrazine-2-carboxylic acid methyl ester was dissolved in 13 ml of N, N-dimethylformamide, 0.67 ml of 1-methylpiperazine and 5 ml of N, N-diisopropylethyl The mixture was heated to 80 C under argon, and the mixture was heated for 2 hours. After heating, the reaction solution was diluted with 65 ml of water and extracted with ethyl acetate. The organic phases were combined and washed with saturated aqueous sodium chloride solution five times, Dried over sodium, filtered and concentrated, and the residue was subjected to column chromatography (dichloromethane: methanol = 99: 1-97: 3, v / v) to give 1.024 g of a yellowish solid in 86.7% yield.
The synthetic route of 33332-25-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Duan Wenhu; Geng Meiyu; Zhao Bin; Ding Jian; Ai Jing; Fan Jun; Peng Xia; Yan Wei; Chen Yi; (77 pag.)CN106146493; (2016); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem