Adding a certain compound to certain chemical reactions, such as: 143591-61-1, name is 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 143591-61-1, Formula: C6H3BrClN3
To a solution of compound 2 (example 1, step 2) (80 mg, 0,28 mmoi) in THE (5 mL) was added NaH (22 mg, 0.56 mmoi, 60 wt% in oil) at RI. The mixture was stirred at RT for 30 minutes, then the product from step 1 (81 rng, 0.35 mmoi) was added. The mixture was heated to 60C for 3 hours. After cooling to RT, the mixture was poured into water (5 mL) and extracted with EtOAc (5 niL x 3). The combined organic layer was washed with brine, driedover MgSO4, filtered and concentrated in vacuo. The residue was purified by Prep.?FIPLC to afford the title compound (70 mg) as a white solid. LRMS mz (M+H) 482.1, 484.1 found, 482.1,484.1
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromo-8-chloroimidazo[1,2-a]pyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LIVERTON, Nigel; KUDUK, Scott D.; BESHORE, Doug C.; MENG, Na; LUO, Yunfu; (127 pag.)WO2016/101119; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem