Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 875781-43-4, name is 2-Bromo-5H-pyrrolo[2,3-b]pyrazine, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Bromo-5H-pyrrolo[2,3-b]pyrazine
5-Bromo-lH-pyrrolo [2,3-b] pyrazine (59.4 g & ‘ 0.3 was added in the reactor Methyl-N-(1-(4-methylpiperazin-1-yl) -2,3-dihydro-1 // – Inden-5-yl) -benzamide(112 mg, 0.3 Mmol), bistriphenylphosphine dioxane 1 E (22 mg & ‘ 0.03 mmol), tricyclic Hexylphosphine (16 mg, 0.06 mmol), cuprous iodide carbonate (99 mg, 0 3 mmol), 6 drops of N, N-diisopropyl Ethylamine was added, and at the end of reaction Kh ‘at 80 C, ethyl acetate and aqueous ammonia were added And washed with saturated NaCl solution, dried over anhydrous Na2S04, filtered, Dried, and purified by column chromatography to give the title compound
The synthetic route of 875781-43-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NANJING SHENGHE PHARMACEUTICAL CO., LTD.; WANG, YONG; ZHAO, LIWEN; LIU, YANG; ZHANG, JINGZHONG; WANG, DEZHONG; GAO, YIPING; CHEN, HONGYAN; ZHANG, CANG; ZHANG, DI; (68 pag.)TWI523856; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem