Some common heterocyclic compound, 957344-74-0, name is 5,8-Dibromoimidazo[1,2-a]pyrazine, molecular formula is C6H3Br2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 957344-74-0
A mixture of known compound 7 (2.75g, 9.90mmol), cyclopropylamine (3.4mL, 49.50mmol) and N, N-diisopropylethylamine (3.5mL, 19.80mL) in 1,4-dioxane (33mL) was stirred at 100C for 16h. The reaction mixture was cooled to room temperature, diluted with ethyl acetate and washed with saturated aqueous NaHCO3. The organic phase was dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated in vacuo. The residue was purified by column chromatography (Hexanes:EtOAc=1:2) to afford the title compound 9 (2.3g, 92%). 1H NMR (300MHz, DMSO-d6) delta 7.88 (s, 1H), 7.82 (br, 1H), 7.58 (s, 1H), 7.49 (s, 1H), 2.85 (m, 1H), 0.68 (m, 2H), 0.63 (m, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 957344-74-0, its application will become more common.
Reference:
Article; Kang, Seok Jong; Lee, Jung Wuk; Chung, Shin Hyuck; Jang, Sun Young; Choi, Jaeyul; Suh, Kwee Hyun; Kim, Young Hoon; Ham, Young Jin; Min, Kyung Hoon; European Journal of Medicinal Chemistry; vol. 163; (2019); p. 660 – 670;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem