Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5049-61-6, name is Pyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of Pyrazin-2-amine
Example 9; Preparation of (5R), (6Z)-6- (7-Methyl-5. 6, 7, 8-tetrahydroimidazor1, 2-alpyrazin-2- vlmethylene)-7-oxo-4-thia-1-aza-bicyclor3. 2. Olhept-2-ene-2-carboxylic acid, sodium salt Step 1 : Imidazo [1, 2-a] pyrazine-2-carboxylic acid ethyl ester: Ethyl bromopyruvate (62.9 g) was added to the DME (258 mL) solution of 2- aminopyrazine (24.8 g) at room temperature and stirred for 2.5 h. The reaction mixture was cooled to 0 C and stirred for 30 min to afford a pale brown precipitate. The precipitate was filtered and washed with Et20 to give pale brown crystals. The suspension of the precipitate (66.1 g) in EtOH (1.29 L) was heated at reflux temperature to turn to clear solution. After refluxing for 2h, the reaction mixture was concentrated under reduced pressure, then mixed with CHCI3 and saturated NaHCO3aq. The mixture was filtered through a pad of Celite and the separated organic layer was dried (MgS04) and filtered. The filtrate was concentrated under reduced pressure. The residue was applied to silica gel column chromatography, then the column was eluted with CHCI3- MeOH (99/1-97/3), and collected fractions were concentrated under reduced pressure followed by recrystallization from CHC13-Et20. The titled compound was obtained as pale pink crystals. Yield : 10.9 g, 22%). ‘H NMR (CDCI3) d 1.46 (t, 3H, J = 7.2 Hz), 4.49 (q, 2H, J = 7.2 Hz), 7.96 (d, 1 H, J = 4.7 Hz), 8.08 (dd, 1H, J= 1.2, 4.7 Hz), 8.26 (s, 1H), 9.21 (d, 1 H, J = 1.2 Hz).
According to the analysis of related databases, 5049-61-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; WYETH; WO2003/93277; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem