Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5521-55-1, name is 5-Methylpyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., SDS of cas: 5521-55-1
A solution of compound 4-6 (0.2 g, 0.3 mmol) in EtOAc (2 mL) was cooled to 0 C, and a solution of HC1 in EtOAc (3 0%, 2 mL) was added. The mixture was stirred at rt until no more gas evolution. The mixture was filtered to afford compound 4-7 as a white solid; the solid was washed with EtOAc (20 mL). A round-bottom flask was charged with compound 4-7, compound 9-1 (0.06 g, 0.4 mmol), EDCI (0.13 g, 0.66 mmol) and HOAT (0.1 g, 0.7 mmol), and then DCM (10 mL) was added under N2. The mixture was cooled to 0 C, and DIPEA (0.2 mL, 1 mmol) was added slowly. After the addition, the resulting mixture was stirred at 30 C for 6 hours. After the reaction was complete, the mixture was quenched with water (10 mL). The resulting mixture was extracted with DCM (10 mL) twice. The combined organic layers were washed with saturated aqueous NaC1 (10 mL) and dried over anhydrous Na2SO4, and then concentrated in vacuo. The residue was purified by silica gel column chromatography eluted with PE : EtOAc (V:V)= 2:1 to give compound 9-2 (0.180 g, 80%) as a white solid. MS (ESI, pos.ion) m/z: 885.3[M+1] and 1HNIVIR (600 IVIHz, CDC13): 5 10.38 (s, 1H), 9.07 (d, J= 0.8 Hz, 1H), 8.44 (s, 1H), 8.15 (d, J= 6.7 Hz, 1H), 7.85 (d, J= 9.1 Hz, 2H), 7.47 (s, 1H), 7.04 (s, 1H), 6.95 (d, J 9.2 Hz, 1H),5.73 (dd, J= 18.2, 8.7 Hz, 1H), 5.50 (s, 1H), 5.02-4.97 (m, 1H), 4.69-4.64 (m, 2H), 4.49 (d, J= 11.5 Hz, 1H), 4.10 (dd, J = 11.6, 3.9 Hz, 1H), 3.77 (s, 3H), 3.22 (dt, J = 13.7, 6.8 Hz, 1H),2.92-2.86 (m, 1H), 2.71 (dd, J= 13.8, 7.7 Hz, 1H), 2.65 (s, 3H), 2.60 (s, 4H), 2.29-2.25 (m, 1H),2.04-2.00 (m, 1H), 1.91 (dd, J= 7.8, 6.1 Hz, 2H), 1.78-1.71 (m, 1H), 1.66 (dd, J= 9.4, 5.9 Hz,1H), 1.53-1.45 (m, 5H), 1.39 (t, J= 13.5 Hz, 7H), 1.16-1.07 (m, 3H), 0.94-0.86 (m, 2H) ppm.
The synthetic route of 5521-55-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; LUO, Huichao; REN, Qingyun; XIONG, Zhimin; LIU, Yang; LEI, Yibo; XIONG, Jinfeng; ZHANG, Jiancun; (123 pag.)WO2016/127859; (2016); A1;,
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