Electric Literature of 16298-03-6,Some common heterocyclic compound, 16298-03-6, name is Methyl 2-aminopyrazine-3-carboxylate, molecular formula is C6H7N3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Methyl 2-amino-3-pyrazine carboxylate (2. 2 g) was dissolved in dry DCM (20 ml) to give a cloudy pale yellow solution, and pyridine (2 ml) in dry DCM (12 ml) was added. The stirred suspension was cooled in an ice bath, and 2,4, 6-trifluorophenylacetyl chloride (3.0 g) in dry DCM (13 ml) was added dropwise. The reaction gradually became a deep orange, and then went clear. It was stirred for 6 hours and stood overnight. The reaction mixture was washed with water, brine, and then dilute hydrochloric acid, and the DCM layer was dried over magnesium sulphate. The solvent was evaporated to yield an orange solid which was triturated with ether, to give methyl 2- [2, 4, 6-TRIFLUOROPHENYLACETYLAMINO]-3-PYRAZINE carboxylate as a yellow solid (1.5 g). LH NM : R (CDC13) 8 ppm: 4.03 (s, 5H), 6.74 (t, 2H), 8.43 (d, LH), 8.61 (d, LH) 10.9 (s, LH).
The synthetic route of 16298-03-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SYNGENTA LIMITED; SYNGENTA PARTICIPATIONS AG; WO2004/56825; (2004); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem