Electric Literature of 36070-80-1,Some common heterocyclic compound, 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid, molecular formula is C5H3ClN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Dissolve 5-chloropyrazine-2-carboxylic acid (2.00 g, 12.62 mmol) in methylene chloride (30 mL) and at room temperature diisopropylethylamine (6.79 g, 39.74 mmol), 2,2,2-trifluoro Ethylamine (1.31 g, 13.24 mmol), O- (7-Azabenzotriazol-1-yl) -N, N, N ‘, N’-tetramethyluronium hexafluorophosphate (5.04 g, 13.24 mmol) is added,Stir at room temperature overnight.Saturated aqueous sodium carbonate was added, and the mixture was extracted twice with ethyl acetate and washed once with saturated brine.The extracted ethyl acetate layer was dried over anhydrous magnesium sulfate and filtered, and then ethyl acetate was evaporated under reduced pressure with an evaporator.The resulting crude product is purified by silica gel chromatography to give 5-chloro-N- (2,2,2-trifluoroethyl) pyrazine-2-Carboxamide (2.97 g, 98.9%, as a pale yellow oil) was obtained.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Chloropyrazine-2-carboxylic acid, its application will become more common.
Reference:
Patent; Nippon Kayaku; Ueno, Shotaro; Hasegawa, Shinji; Atarashi, Daiju; Kobayashi, Takeshi; Miyake, Takaaki; Asano, Shou; Sumi, Takuto; (116 pag.)JP2019/94290; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem