Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 912773-21-8, name is 2-Bromo-5-chloropyrazine, A new synthetic method of this compound is introduced below., COA of Formula: C4H2BrClN2
Intermediate C-3 2-chloro-5-((2-(trifluoromethyl)pyridin-3-yl)thio)pyrazine A mixture of 2-(trifluoromethyl)pyridine-3-thiol (100 mg, 0.558 mmol), 2- bromo-5-chloro-pyrazine (195 mu, 0.670 mmol), Pd2(dba)3 (12.8 mg, 0.014 mmol), XantPhos (17.8 mg, 0.031 mmol), and DIPEA (144 mg, 1.12 mmol) in dioxane (degassed, 2.79 n L) was stirred for 2.5 h at 120 C. After cooling to RT, the reaction mixture was filtered through a pad of Celite followed by EtOAc (10 mL) wash. The combined filtrates were concentrated under reduced pressure and the resulting residue was purified by silica chromatography (0 to 25% gradient of EtO Ac/heptane) to give 2-chloro-5-((2-(trifluoromethyl)pyridin-3-yl)thio)pyrazine (252 mg, 0.864 mmol) as a brown oil. NMR (400 MHz, Chloroform- ) delta ppm 8.68 (dd, 7=4.7, 1.5 Hz, 1 H), 8.25 (d, 7=1.5 Hz, 1 H), 8.18 (d, 7=1.5 Hz, 1 H), 7.98 (dd, 7=8.1, 1.5 Hz, 1 H), 7.49 (dd, 7=8.0, 4.7 Hz, 1 H). MS m/z 292.0 (M+H)+.
The synthetic route of 912773-21-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; CHEN, Zhuoliang; FORTANET, Jorge Farcia; JOUK, Andriana; KARKI, Rajesh; LAMARCHE, Matthew J.; LIU, Gang; PALERMO, Mark G.; PEREZ, Lawrence Blas; SARVER, Patrick James; SHULTZ, Michael David; SENDZIK, Martin; TOURE, Bakary-Barry; YU, Bing; (173 pag.)WO2016/203406; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem