Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 113305-94-5, name is 5-Aminopyrazine-2-carbonitrile, A new synthetic method of this compound is introduced below., HPLC of Formula: C5H4N4
To a suspension of 5-aminopyrazine-2-carbonitrile (414 mg, 3.44 mmol) in THF (10 mL) was added sodium hydride (230 mg, 5.73 mmol) at 0 C and the resulting mixture was then stirred at ambient temperature for 1 h. Compound 305-4 (1.0 g, 2.87 mmol) was added and stirred at 60 C for 4 h. The reaction mixture was quenched with ice water and extracted with ethyl acetate. The organic layer was washed with water and brine, dried over Na2SO4 and concentrated to afford the title compound 306-4 as a yellow solid (500 mg, 42% yield). LCMS:420.9 [M+1]. ?H NIVIR (400 1VIFIz, DMSO-d6): 2.36 (s, 3H), 3.35 (s, 3H), 3.77 (s, 3H), 5.21 (s, 2H), 5.68 (s, 1H), 6.86-6.88 (m, 2H), 8.63 (d, J 1.2 Hz, 1H), 8.86 (d, J1.2 Hz, 1H), 13.89 (s, 1H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; PHARMAENGINE, INC.; CAI, Xiong; QIAN, Changgeng; WANG, Yanong Daniel; (98 pag.)WO2017/132928; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem