Adding a certain compound to certain chemical reactions, such as: 36070-75-4, name is 5-Chloropyrazine-2-carbonitrile, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 36070-75-4, COA of Formula: C5H2ClN3
1-((2S,4/?)-4-amino-6-bromo-2-methyl-3,4-dihydroquinolin-1 (2/-/)-yl)ethanone (for a preparation, see Intermediate 1 ) (50 mg, 0.177 mmol), 5-chloropyrazine-2-carbonitrile (37.0 mg, 0.265 mmol) and DIPEA (0.123 mL, 0.706 mmol) were combined in NMP (1 .5 mL) and heated in a sealed flask under microwave irradiation to 200C for 1 h. The mixture was partitioned between water (150 mL) and EtOAc (4×100 mL). The organic layers were combined, washed with brine (2×100 mL), dried by passing through a hydrophobic frit, and concentrated in vacuo. The resulting residue was purified by chromatography (25 g column, EtOAc/cyclohexane gradient) to give 5-(((2S,4/?)-1-acetyl- 6-bromo-2-methyl-1 ,2,3,4-tetrahydroquinolin-4-yl)amino)pyrazine-2-carbonitrile (61 mg, 0.158 mmol, 89 % yield) as a brown gum.LCMS (Formate, 2 min), Rt = 0.94 mins, MH+ = 386/388.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloropyrazine-2-carbonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLAXOSMITHKLINE LLC; AMANS, Dominique; DEMONT, Emmanuel Hubert; MITCHELL, Darren Jason; SEAL, Jonathan Thomas; WO2012/143415; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem