Brief introduction of 58138-79-7

The synthetic route of 58138-79-7 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 58138-79-7, name is 2,6-Diiodopyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 2,6-Diiodopyrazine

1. 2-Iodo-6-dimethylaminopyrazine A solution of 2,6-diiodopyrazine (6 g, 18.1 mmol) in methanol (50 ml) and dimethylamine (40% aqueous solution, 200 ml) was heated at reflux for 1 h. The methanol was removed under vacuum, the aqueous saturated with potassium carbonate and extracted with dichloromethane (3*100 ml). The combined extracts were dried (Na2 SO4), evaporated and the residue purified by chromatography through silica-gel eluding with dichloromethane. The product (4 g) was obtained as a low melting solid, m.p. 46-48 C., m/e 249 (M+); delta (360 MHz, CDCl3) 3.10 (6H, s, 2*Me); 7.87 (1H, s, pyrazine-H); 8.01 (1H, s, pyrazine-H).

The synthetic route of 58138-79-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Merck Sharp & Dohme Limited; US5260293; (1993); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Analyzing the synthesis route of C5H4ClN3O

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Chloropyrazine-2-carboxamide, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 21279-62-9, name is 3-Chloropyrazine-2-carboxamide, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 21279-62-9, Quality Control of 3-Chloropyrazine-2-carboxamide

Compound 9 is prepared by reaction of 4-chlorophenylbydrazine (3 mmol) with 3- chloropyrazine-2-carboxamide (ifi, 1 mmol) in 3 mL methanol and pyridine (1 inmol). The reaction is performed in a microwave reactor at the temperature 140 C, pressure 15 kPa and an output of 120 W during 30 miii. After completing the reaction, product 9 was isolated and purified by column chromatography on silica gel (mobile phase: hexane I ethyl acetate 1:1), yield 23%. Analytical data for compound 9: Brown crystalline solid; Mp. 155.3-156.2C; Elemental analysis calculated for C,1H10C1N5O (m.w. 263.68): 50.10% C, 3.82% H, 26.56% N; found 50.27% C, 3.72% H, 26.3 5% N; IR (ATR-Ge, cm?): 3453 (-NH-), 3202 (-CONH2), 1686 (-C=O), 1596, 1527, 1491, 1405 (pyr); ?H-NMR (300 MHz, CDCI3) oe 11.40 (IH, bs, NH), 8.45 (1H, bs, NH), 8.40 (111, d, J 2.3 Hz, H5), 8.05 (1H, d, J- 2.3 Hz, H6), 8.01 (1H, bs, NH), 7.75-7.67 (211, m, AA?, BB?, H2?, H6?), 7,40-7.32 (211, m, AA?, BE?, H3?, H5??); ?3C NMR (75 M}lz, DMSO) 8 168.9, 151.7, 145.8, 138.3, 132.9, 128.9, 127.7, 126.1, 121.4; Lipophilicity: calc. values log? = 0.34; experimental determined values log k = 0.5996.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Chloropyrazine-2-carboxamide, and friends who are interested can also refer to it.

Reference:
Patent; UNIVERZITA KARLOVA V PRAZE; DOLEZAL, Martin; ZITKO, Jan; JANDOUREK, Ondrej; SERVUSOVA-VANASKOVA, Barbora; (31 pag.)WO2016/95877; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

The important role of 4858-85-9

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,3-Dichloropyrazine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 4858-85-9, name is 2,3-Dichloropyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4858-85-9, Recommanded Product: 4858-85-9

To a mixture of 2,3-dichloro-pyrazine ( 3.0 g, 20 mmol ) and tert-butyl ((1S,3S)- 3-hydroxycyclobutyl)carbamate (see PREPARATION 4A; 3.65 g, 20 mmol) in DMSO (50 mL) was added CS2CO3 ( 13.2 g, 40 mmol), and then the mixture was stirred at 80C overnight. The reaction mixture was diluted with water and filtered. The filter cake was washed with water, and dried to give tert-butyl ((lS,3S)-3-((3-chloropyrazin-2-yl)oxy)cyclobutyl)carbamate (5.7 g, 19.0 mmol, 96.6%). ESI-MS (M+l): 300 calc. for Ci3Hi8ClN303 299.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,3-Dichloropyrazine, and friends who are interested can also refer to it.

Reference:
Patent; AMGEN INC.; ALLEN, Jennifer; FROHN, Michael; HARRINGTON, Paul; PICKRELL, Alexander; RZASA, Robert; SHAM, Kelvin; HU, Essa; WO2011/143366; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Extracurricular laboratory: Synthetic route of C6H6N2O

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Acetylpyrazine, and friends who are interested can also refer to it.

Related Products of 22047-25-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 22047-25-2 name is Acetylpyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 1 Preparation of 4,4-difluoro-1-(2-pyrazinyl)-butane-1,3-dione Ethyl difluoroacetate (2.23 g, 18 mmol) was placed in a 100 mL round bottom flask and dissolved in ether (10 mL). To the stirred solution was added 25 weight % sodium methoxide (4.68 g, 22 mmol) followed by acetylpyrazine (2.00 g,16 mmol). After two hours stirring at room temperature, a precipitate formed and THF (10 mL) was added to the reaction. The reaction was stirred an additional 25.9 hours, then treated with 3N HCl (10 mL). The organic layer was collected, washed with brine (20 mL), dried over MgSO4, and concentrated in vacuo and recrystallized from methylene chloride/isooctane to give the diketone as a brown solid (2.23 g, mp 103-110 C., 68%) 1 H NMR (CDCl3) 300 MHz 14.00 (br s, 1H), 9.31 (d, J=1.4 Hz, 1H), 8.76 (d, J=2.4 Hz, 1H), 8.68 (dd, J= 1.4 Hz 2.4 Hz, 1H), 7.20 (s, 1H), 6.03 (t, J=54.0 Hz, 1H); 19 F NMR (CDCl3) 300 MHz: -127.16 (d); M+ 200.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Acetylpyrazine, and friends who are interested can also refer to it.

Reference:
Patent; G.D. Searle & Co.; US5521207; (1996); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Introduction of a new synthetic route about C5H5N3O2

The synthetic route of 5-Aminopyrazine-2-carboxylic acid has been constantly updated, and we look forward to future research findings.

Related Products of 40155-43-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 40155-43-9, name is 5-Aminopyrazine-2-carboxylic acid belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

In a 100mL one-neck flask, the2-amino-pyrazine carboxylic acid (1.00g, 7.19mmol) was dissolved in DMF (45mL),was added 1- (3-dimethylaminopropylAminopropyl) -3-ethylcarbodiimidehydrochloride (3.51g, 8.95mmol) and diisopropylethylamine amine (2.5mL,14.0mmol), stirred for 15After min, adding1-tert-butoxycarbonyl-piperazine (1.30g, 6.98mmol), the reaction at roomtemperature 15h. After completion of the reaction the organic solvent wasdistilled off under reduced pressure, the residueIt was purified by column chromatography(methylene chloride / methanol (V / V) = 10/1), to give a pale yellow oil(1.85g, 83.70%).

The synthetic route of 5-Aminopyrazine-2-carboxylic acid has been constantly updated, and we look forward to future research findings.

Reference:
Patent; East Sunshine Pharmaceutical Co., Ltd.; Liu, Bing; Zhang, Yingjun; Nie, Linlin; Bai, Shun; Zheng, Changchun; Nie, biao; Li, Zhiyong; Tan, Yumei; (61 pag.)CN105294737; (2016); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Continuously updated synthesis method about 55557-52-3

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Adding a certain compound to certain chemical reactions, such as: 55557-52-3, name is 3-Chloropyrazine-2-carbonitrile, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 55557-52-3, COA of Formula: C5H2ClN3

Sodium hydride (60%, 40 mg, 1 mmol, 1 eq.)Was dissolved in dry THF (3 mL)And (3,3-bismethoxy cyclobutanyl) methanol (161 mg, 1.1 mmol, 1.1 eq.)In dry THF (1 mL).The reaction solution was stirred at room temperature for 1 h,Then 3-chloropyrazine-2-carbonitrile (139 mg, 1 mmol, 1 eq.) Was added,The resulting reaction mixture was stirred at room temperature for 4 h,Then diluted with 10 mL of water,The mixture was extracted with EtOAc (15 mL x 2)The organic phase was washed with saturated sodium chloride solution,And then dried over anhydrous sodium sulfate,Then filtered,The filtrate was concentrated under reduced pressure.The residue was purified by silica gel column chromatography (eluent:PE / EtOAc (v / v) = 4/1) to give the title compound (142 mg, 54%) as a white solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; East Sunshine Pharmaceutical Co., Ltd. of Guangdong; Ren, Qingyun; Luo, Huichao; Tang, Changhua; Zhang, Jiancun; Zhang, Yingjun; (30 pag.)CN104447583; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Some tips on C6H3Br2N3

According to the analysis of related databases, 63744-22-9, the application of this compound in the production field has become more and more popular.

Application of 63744-22-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 63744-22-9 as follows.

Diisopropylethylamine (2.4 mL, 13.62 mmol) and cyclopropylamine (943 muL, 13.62 mmol) were added to commercially available (Ark Pharm, Inc.) 6,8-dibromoimidazo[1,2-a]pyrazine (2.51 g, 9.08 mmol) dissolved in 2-propanol (9 mL). The solution was placed in an 80 C. oil bath. After 4.5 h, the volatiles were removed in vacuo. The brown residue was partitioned between dichloromethane (50 mL) and water (50 mL). The organic layer was washed further with water (50 mL) and then brine (50 mL). The organic layer was dried over MgSO 4, filtered and concentrated in vacuo. The residue was purified via a filtration over a short plug of silica gel (40% EtOAc/hexanes) and the filtrate was concentrated in vacuo to afford 6-bromo-N-cyclopropylimidazo[1,2-a]pyrazin-8-amine (2.19 g, 95%) as a light brown solid.

According to the analysis of related databases, 63744-22-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SENHWA BIOSCIENCES INCORPORATED; HADDACH, MUSTAPHA; TRAN, JOE A; PIERRE, FABRICE; REGAN, COLLIN F; RAFFAELE, NICHOLAS B; RAVULA, SUCHITRA; RYCKMAN, DAVID M; (482 pag.)JP5802676; (2015); B2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Simple exploration of 24241-18-7

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 24241-18-7, its application will become more common.

Some common heterocyclic compound, 24241-18-7, name is 2-Amino-3,5-dibromopyrazine, molecular formula is C4H3Br2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 24241-18-7

3,5-Dibromo-pyrazin-2-ylamine (5 g, 19.8 mmol), 2-chloro-acetone (18.3 g, 198 mmol) and dioxane (40 ml) were heated at reflux temperature for 16 h. The r.m was concentrated under reduced pressure, and the residue was triturated with DIPE. Yield: 3.6 g of intermediate 101 (55 %).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 24241-18-7, its application will become more common.

Reference:
Patent; ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC; GIJSEN, Henricus, Jacobus, Maria; VELTER, Adriana, Ingrid; MACDONALD, Gregor, James; BISCHOFF, Francois, Paul; WU, Tongfei; VAN BRANDT, Sven, Franciscus, Anna; SURKYN, Michel; ZAJA, Mirko; PIETERS, Serge, Maria, Aloysius; BERTHELOT, Didier, Jean-Claude; DE CLEYN, Michel, Anna, Jozef; OEHLRICH, Daniel; WO2010/89292; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Simple exploration of C6H3Br2N3

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6,8-Dibromoimidazo[1,2-a]pyrazine, other downstream synthetic routes, hurry up and to see.

Application of 63744-22-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 63744-22-9, name is 6,8-Dibromoimidazo[1,2-a]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.

Intermediate Example 2-1 : Preparation of 6-bromo-8-methylsulfanyl- imidazo[1 ,2-a]pyrazineTo a stirred suspension of intermediate example 1 -1 6,8-dibromo-imidazo[1 ,2- ajpyrazine (489 g, 1766 mmol) in MeOH (2900 mL) at -20 C was dropwise added a solution of sodium methan thiolate (225 g, 3214 mmol, 1 .8 eq) in 800 mL water. After stirring overnight, the clear solution was poured on 30 L water and the yellowish precipitate was filtered, washed with 3 L water and dried in vaccuo to yield 301 g 6-bromo-8-methylsulfanyl-imidazo[1 ,2-a]pyrazine (69.8 %). 1H-NMR (300 MHz, d6-DMSO): delta = 8.64 (1 H, s), 8.00 (1 H, d), 7.66 (1 H, d2.54 (3H, s) ppm.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6,8-Dibromoimidazo[1,2-a]pyrazine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; KOPPITZ, Marcus; KLAR, Ulrich; JAUTELAT, Rolf; KOSEMUND, Dirk; BOHLMANN, Rolf; BADER, Benjamin; LIENAU, Philip; SIEMEISTER, Gerhard; WO2012/80234; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem

Brief introduction of 33332-28-4

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 33332-28-4, name is 2-Amino-6-chloropyrazine, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Amino-6-chloropyrazine

A solution of 2-amino-6-chloropyrazine (25g, 193.1 mmol) in MeOH (500 ml_) was treated with NBS (34.3 g, 193.1 mmol), portion-wise, over 1 hour. The resulting mixture was stirred for 16 hours thereafter. TLC analysis at this time shows a small amount of starting material remaining. Another 1.4 g NBS added and reaction heated to 50 0C for 2 hours. The mixture15 was then cooled to 38 0C and treated with NCS (25.8 g, 193.1 mmol). The reaction mixture was heated to 500C for 16 hours thereafter. The mixture was then cooled to room temperature and treated with water (500 ml_). The precipitate was collected by filtration and dried in a vacuum dessicator to afford 45.4 g (97% yield) of 2-amino-5-bromo-3,6- dichloropyrazine as a white solid: 13C NMR (75 MHz, CDCI3) delta 149.9 (s), 145.6 (s), 129.6 (s),20 121.5 (S). LCMS (15-95% gradient acetonitrile in 0.1 % TFA over 10 min), single peak retention time = 4.51 min on 30 mm column, (M+H)+ = 244, (M+H+ACN)* = 285.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; MALLINCKRODT INC.; WO2007/149479; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem