These common heterocyclic compound, 4744-50-7, name is 2,3-Pyrazinecarboxylic anhydride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C6H2N2O3
General procedure: 4-Aminophenyl selenocyanate (2mmol) was dissolved in dry acetone (15mL) and the corresponding anhydride (2mmol) then added. The reaction was then stirred for a variable time of 12h up to 48h at room temperature. Reaction was quenched with water, compound was then filtered and purified by stirring or washing with solvents such as n-hexane and ethyl ether. The chemical shifts assignment in NMR spectroscopy for these compounds is exemplified in Fig.12.
The synthetic route of 2,3-Pyrazinecarboxylic anhydride has been constantly updated, and we look forward to future research findings.
Reference:
Article; Garnica, Pablo; Encio, Ignacio; Plano, Daniel; Palop, Juan A.; Sanmartin, Carmen; European Journal of Medicinal Chemistry; vol. 175; (2019); p. 234 – 246;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem