In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 14508-49-7 as follows. Quality Control of 2-Chloropyrazine
In a sealed tube, 30 mL of dry toluene was degazed with Argon during 15 minutes, palladium acetate (114 mg, 0.17 mmol, 0.04 eq.) and racemic-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (106 mg, 0.17 mmol, 0.04 eq.) were added and the mixture was degazed with Argon for 10 minutes. Then 2-chloropyrazine (500 mg, 4.37 mmol, 1.0 eq.), 4-amino-1-Boc-piperidine (1.05 g, 5.24 mmol, 1.2 eq.) and sodium tert-butoxide (587 mg, 6.11 mmol, 1.4 eq.) were added and the mixture was stirred at 70 C. overnight. The reaction was concentrated in vacuum. The resulting crude product was purified by flash chromatography on silica gel, eluting with 100% ethyl acetate to afford 106a (1.0 g, 82%).
According to the analysis of related databases, 14508-49-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Vetoquinol SA; US2009/221565; (2009); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem