Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89123-58-0, name is 5-Bromopyrazine-2,3-diamine, A new synthetic method of this compound is introduced below., Recommanded Product: 89123-58-0
The compound 5-bromo-2,3-diaminopyrazine 1b (12.0 g, 63.8 mmol) was added to triethyl orthoformate (94.4 g, 638 mmol), and the reaction mixture was reacted at 145 C overnight. Complete the reaction monitored by TLC, cooled and concentrated by column (v / v, dichloromethane / methanol = 100: 1-30: 1) to give the title compound 1c (10.0g, 50.5mmol), in a yield of 79.4%
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Shanghai Huahuituo Pharmaceutical Technology Co., Ltd.; Zhejiang Huahai Pharmaceutical Co., Ltd.; Xu Xin; Zhang Tian; Li Yunfei; Wang Guan; Zhu Weibo; Li Qiang; Qu Minkai; Zhang Linli; Song Jinqian; Liu Lei; Chen Haiji; Liu Qiang; Wang Yijin; Ge Jian; (67 pag.)CN109535164; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem