Related Products of 71257-38-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 71257-38-0 name is 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 1112,2-Dimethyl-1 -(7-(phenylethynyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2(1H)- yl)propan-1-one[00350] Pivaloyl chloride (3.27 g, 3.34 mL, 27.2 mmol) is added dropwise at 0 C to a solution of 1 ,2,3,4-tetrahydropyrrolo[1 ,2-a]pyrazine (3.01 g, 24.7 mmol) (WO2009/90055) and TEA (4.60 mL, 32.6 mmol) in DCM (40 mL). The resulting mixture is stirred at 0 C for 15 min and washed with an aqueous citric acid solution (10%). The organic phase is dried over MgSO and concentrated at reduced pressure. The obtained residue is purified by column chromatography (silica gel, DCM/acetone, 10:1 ) to give 1 -(3,4-dihydropyrrolo[1 ,2-a]pyrazin-2(1 H)-yl)-2,2-dimethylpropan-1 -one (3.10 g, 61 %) as a yellowish crystalline intermediate product.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,2,3,4-Tetrahydropyrrolo[1,2-a]pyrazine, and friends who are interested can also refer to it.
Reference:
Patent; MERZ PHARMA GmbH & CO. KGaA; ZEMRIBO, Ronalds; FOTINS, Juris; ABEL, Ulrich; KUBAS, Holger; MEYER, Udo; WOLTER, Falko Ernst; HECHENBERGER, Mirko; WO2012/172093; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem